Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2170404..2171054 Replicon chromosome
Accession NZ_CP128515
Organism Mannheimia haemolytica strain 192964

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag QTV66_RS11245 Protein ID WP_006249411.1
Coordinates 2170404..2170793 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag QTV66_RS11250 Protein ID WP_006249412.1
Coordinates 2170794..2171054 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV66_RS11190 2165675..2166484 - 810 WP_006250123.1 metal ABC transporter permease -
QTV66_RS11195 2166477..2167337 - 861 WP_006250124.1 metal ABC transporter permease -
QTV66_RS11200 2167411..2168196 - 786 WP_006251768.1 hypothetical protein -
QTV66_RS11240 2169146..2170384 - 1239 WP_006253630.1 peptidase T -
QTV66_RS11245 2170404..2170793 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
QTV66_RS11250 2170794..2171054 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QTV66_RS11255 2171170..2171382 - 213 WP_006251765.1 BrnA antitoxin family protein -
QTV66_RS11260 2171383..2171670 - 288 WP_006251764.1 BrnT family toxin -
QTV66_RS11265 2171833..2175295 - 3463 Protein_2178 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T284707 WP_006249411.1 NZ_CP128515:c2170793-2170404 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT284707 WP_006249412.1 NZ_CP128515:c2171054-2170794 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References