Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1833875..1834397 Replicon chromosome
Accession NZ_CP128511
Organism Mannheimia haemolytica strain 202699

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag QTV69_RS09470 Protein ID WP_006249269.1
Coordinates 1834101..1834397 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag QTV69_RS09465 Protein ID WP_006249270.1
Coordinates 1833875..1834117 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTV69_RS09440 1829713..1830802 - 1090 Protein_1821 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
QTV69_RS09445 1830976..1831617 - 642 WP_006249274.1 orotate phosphoribosyltransferase -
QTV69_RS09450 1831740..1832582 - 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
QTV69_RS09455 1832642..1833217 + 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QTV69_RS09460 1833195..1833863 - 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
QTV69_RS09465 1833875..1834117 - 243 WP_006249270.1 CopG family antitoxin Antitoxin
QTV69_RS09470 1834101..1834397 - 297 WP_006249269.1 BrnT family toxin Toxin
QTV69_RS09475 1834524..1837436 - 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
QTV69_RS09480 1837597..1837896 - 300 WP_006249265.1 hypothetical protein -
QTV69_RS09485 1838017..1839342 - 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T284691 WP_006249269.1 NZ_CP128511:c1834397-1834101 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT284691 WP_006249270.1 NZ_CP128511:c1834117-1833875 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References