Detailed information of TA system TA028468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 3504391..3505055
• Replicon: chromosome
• Accession: NC_019395
• Organism: Propionibacterium acidipropionici ATCC 4875

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K7SPA7
• Locus tag: PACID_RS16100
• Protein ID: WP_015071957.1
• Coordinates: 3504627..3505055 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K7RSL2
• Locus tag: PACID_RS16095
• Protein ID: WP_015071956.1
• Coordinates: 3504391..3504630 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PACID_RS18010	3499953..3500579	-	627	WP_095532357.1	L,D-transpeptidase	-
PACID_RS16075	3500860..3502407	-	1548	WP_015071952.1	glycoside hydrolase family 32 protein	-
PACID_RS16080	3502574..3503533	+	960	WP_015071953.1	PfkB domain-containing protein	-
PACID_RS16085	3503686..3504033	-	348	WP_015071954.1	type II toxin-antitoxin system PemK/MazF family toxin	-
PACID_RS16090	3504020..3504247	-	228	WP_015071955.1	ribbon-helix-helix domain-containing protein	-
PACID_RS16095	3504391..3504630	+	240	WP_015071956.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
PACID_RS16100	3504627..3505055	+	429	WP_015071957.1	PIN domain-containing protein	Toxin
PACID_RS16105	3505071..3507221	+	2151	WP_015071958.1	NAD(+) synthase	-
PACID_RS16110	3507315..3507719	-	405	WP_015071959.1	nitrite reductase small subunit NirD	-
PACID_RS16115	3507746..3509731	-	1986	WP_198027851.1	nitrite reductase large subunit NirB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-127)

Antitoxin

• SpoVT-AbrB domain (4-42)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 14652.53 Da
• Isoelectric Point: 5.1153

>T28468 WP_015071957.1 NC_019395:3504627-3505055 [Acidipropionibacterium acidipropionici ATCC 4875]
MSASPQLAVDTSIAVPLLVASHVQHRAVAEWASGRALTLSGHALIETYSVLTRLPGDARVSPEDAVTLIEDNFGDPLILS
ASATRRVPRDLASAGVAGGAAYDGLVAIAALEHGATLVTRDARARSTYEALGAQVRVLADEA

Nucleotide

• Length: 429 bp

>T28468 NC_019395:3504627-3505055 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGAGCGCGTCTCCTCAGCTGGCCGTCGACACCAGCATCGCGGTTCCCCTGCTGGTCGCATCTCATGTGCAACACCGCGC
TGTCGCCGAATGGGCATCTGGAAGGGCATTGACCCTCAGCGGGCACGCCCTCATCGAGACGTACTCCGTGCTCACCCGCC
TGCCCGGTGACGCGCGTGTCTCCCCCGAGGACGCCGTGACCCTCATCGAGGACAACTTCGGCGACCCGCTGATCCTCTCG
GCTTCCGCCACGCGCCGGGTGCCCCGGGACCTCGCCTCTGCAGGCGTGGCCGGCGGCGCCGCCTATGACGGCCTGGTCGC
CATTGCCGCACTTGAGCACGGTGCGACCCTGGTCACCCGAGACGCCCGGGCCAGGTCGACGTACGAAGCCCTCGGGGCTC
AGGTGCGGGTTCTCGCCGACGAAGCCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8365.45 Da
• Isoelectric Point: 5.0336

>AT28468 WP_015071956.1 NC_019395:3504391-3504630 [Acidipropionibacterium acidipropionici ATCC 4875]
MEAVIDSGGRVVLPKRLRDALGLTPGTTVDITAYGAGLQLIPGGRTARLEREDDGRLVSHGGTEVTDEAMYALIDSGRR

Nucleotide

• Length: 240 bp

>AT28468 NC_019395:3504391-3504630 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGGAAGCTGTGATCGATTCTGGCGGACGCGTCGTGCTCCCCAAGCGCTTGCGCGACGCACTGGGACTGACCCCCGGGAC
GACGGTGGACATCACCGCCTATGGCGCCGGACTTCAGCTCATCCCCGGCGGCCGCACCGCCCGACTTGAGCGAGAGGATG
ACGGTCGACTCGTCTCCCACGGTGGCACCGAGGTCACCGACGAGGCGATGTACGCGCTCATCGACTCGGGCCGGCGATGA

Structures

Toxin

• AlphaFold DB: K7SPA7

Antitoxin

• AlphaFold DB: K7RSL2