Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3575837..3577058 Replicon chromosome
Accession NZ_CP128507
Organism Pseudomonas aeruginosa strain WS27-3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag QUC27_RS16530 Protein ID WP_003102740.1
Coordinates 3576480..3577058 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QUC27_RS16525 Protein ID WP_003088112.1
Coordinates 3575837..3576391 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC27_RS16500 (QUC27_16500) 3571405..3571956 + 552 WP_003450159.1 XRE family transcriptional regulator -
QUC27_RS16505 (QUC27_16505) 3571953..3572351 - 399 WP_003117664.1 NADH-quinone oxidoreductase subunit A -
QUC27_RS16510 (QUC27_16510) 3572364..3572687 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QUC27_RS16515 (QUC27_16515) 3573018..3573479 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QUC27_RS16520 (QUC27_16520) 3573484..3575679 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QUC27_RS16525 (QUC27_16525) 3575837..3576391 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QUC27_RS16530 (QUC27_16530) 3576480..3577058 + 579 WP_003102740.1 HD domain-containing protein Toxin
QUC27_RS16535 (QUC27_16535) 3577168..3578355 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
QUC27_RS16540 (QUC27_16540) 3578345..3580516 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
QUC27_RS16545 (QUC27_16545) 3580506..3581783 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T284679 WP_003102740.1 NZ_CP128507:3576480-3577058 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT284679 WP_003088112.1 NZ_CP128507:3575837-3576391 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References