Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2605446..2606393 Replicon chromosome
Accession NZ_CP128507
Organism Pseudomonas aeruginosa strain WS27-3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QUC27_RS12430 Protein ID WP_289360052.1
Coordinates 2606214..2606393 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QUC27_RS12425 Protein ID WP_228214486.1
Coordinates 2605446..2606168 (-) Length 241 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC27_RS12390 (QUC27_12390) 2600834..2601052 + 219 WP_003451709.1 Cro/CI family transcriptional regulator -
QUC27_RS12395 (QUC27_12395) 2601292..2601783 - 492 WP_171941815.1 hypothetical protein -
QUC27_RS12400 (QUC27_12400) 2601887..2602459 + 573 WP_289360048.1 hypothetical protein -
QUC27_RS12405 (QUC27_12405) 2602462..2603346 + 885 WP_289360049.1 hypothetical protein -
QUC27_RS12410 (QUC27_12410) 2603249..2604004 + 756 WP_289360050.1 replication protein P -
QUC27_RS12415 (QUC27_12415) 2603997..2604446 + 450 WP_128723289.1 RusA family crossover junction endodeoxyribonuclease -
QUC27_RS12420 (QUC27_12420) 2604475..2605344 + 870 WP_128723290.1 hypothetical protein -
QUC27_RS12425 (QUC27_12425) 2605446..2606168 - 723 WP_228214486.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QUC27_RS12430 (QUC27_12430) 2606214..2606393 - 180 WP_289360052.1 type II toxin-antitoxin system HicA family toxin Toxin
QUC27_RS12435 (QUC27_12435) 2606479..2606859 + 381 WP_033994419.1 putative holin -
QUC27_RS12440 (QUC27_12440) 2606852..2607175 + 324 WP_050585148.1 phage holin family protein -
QUC27_RS12445 (QUC27_12445) 2607239..2607427 + 189 WP_003451692.1 DUF2158 domain-containing protein -
QUC27_RS12450 (QUC27_12450) 2607471..2608052 + 582 WP_289360055.1 terminase small subunit -
QUC27_RS12455 (QUC27_12455) 2608049..2609374 + 1326 WP_213910750.1 terminase family protein -
QUC27_RS12460 (QUC27_12460) 2609377..2610732 + 1356 WP_003451684.1 DUF4055 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2581040..2635179 54139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.69 Da        Isoelectric Point: 11.4350

>T284678 WP_289360052.1 NZ_CP128507:c2606393-2606214 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVTFEAGKGSHFKITAPNGKTTTFANHGAKEMPEPTRKAIIKQLGL

Download         Length: 180 bp

Antitoxin


Download         Length: 241 a.a.        Molecular weight: 27041.54 Da        Isoelectric Point: 4.7445

>AT284678 WP_228214486.1 NZ_CP128507:c2606168-2605446 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSFGDDREHAIQEAMDAIETTLSLYVDARKPIPEATPPEEGEHVVHLPAVTVA
KIALWNEMMKRGMRKSDLCKLLGIAQTQGDRLVDFLHNTKMDAVEAALLALGTRLRQSVEVRFDWVKLRHERADDVILVE
VWCEMVSSGHDETGNEQGWVSLPSQLSTTWNQIKAMEAHQFATGRQFSISVDDDRPGESRFESLGRIHLPVTFYAARVSA

Download         Length: 723 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References