Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1876754..1878262 Replicon chromosome
Accession NZ_CP128507
Organism Pseudomonas aeruginosa strain WS27-3

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag QUC27_RS08765 Protein ID WP_003119682.1
Coordinates 1876754..1877341 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag QUC27_RS08770 Protein ID WP_003091607.1
Coordinates 1877408..1878262 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC27_RS08760 (QUC27_08760) 1873009..1876488 - 3480 WP_023115144.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QUC27_RS08765 (QUC27_08765) 1876754..1877341 + 588 WP_003119682.1 GNAT family protein Toxin
QUC27_RS08770 (QUC27_08770) 1877408..1878262 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
QUC27_RS08775 (QUC27_08775) 1878359..1880524 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
QUC27_RS08780 (QUC27_08780) 1880699..1882573 + 1875 WP_010793244.1 MFS transporter -
QUC27_RS08785 (QUC27_08785) 1882634..1882843 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T284677 WP_003119682.1 NZ_CP128507:1876754-1877341 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT284677 WP_003091607.1 NZ_CP128507:1877408-1878262 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References