Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 145746..146251 Replicon chromosome
Accession NZ_CP128507
Organism Pseudomonas aeruginosa strain WS27-3

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag QUC27_RS00675 Protein ID WP_003121619.1
Coordinates 145746..146027 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag QUC27_RS00680 Protein ID WP_003112628.1
Coordinates 146024..146251 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC27_RS00650 (QUC27_00650) 140997..142346 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
QUC27_RS00655 (QUC27_00655) 142395..143081 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QUC27_RS00660 (QUC27_00660) 143182..143916 + 735 WP_003117208.1 GntR family transcriptional regulator -
QUC27_RS00665 (QUC27_00665) 144096..144506 + 411 WP_003101225.1 aegerolysin family protein -
QUC27_RS00670 (QUC27_00670) 144538..145446 - 909 WP_003083769.1 LysR family transcriptional regulator -
QUC27_RS00675 (QUC27_00675) 145746..146027 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
QUC27_RS00680 (QUC27_00680) 146024..146251 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
QUC27_RS00685 (QUC27_00685) 146427..147047 - 621 WP_003101226.1 hypothetical protein -
QUC27_RS00690 (QUC27_00690) 147148..147648 + 501 WP_003101228.1 LEA type 2 family protein -
QUC27_RS00695 (QUC27_00695) 147721..148062 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QUC27_RS00700 (QUC27_00700) 148144..149571 - 1428 WP_003083784.1 GABA permease -
QUC27_RS00705 (QUC27_00705) 149740..151233 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T284676 WP_003121619.1 NZ_CP128507:c146027-145746 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT284676 WP_003112628.1 NZ_CP128507:c146251-146024 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References