Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4492478..4493736 Replicon chromosome
Accession NZ_CP128506
Organism Pseudomonas aeruginosa strain Fe11-1

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QUC24_RS20760 Protein ID WP_003086331.1
Coordinates 4492478..4493233 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QUC24_RS20765 Protein ID WP_003086329.1
Coordinates 4493368..4493736 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC24_RS20750 (QUC24_20750) 4487647..4490190 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
QUC24_RS20755 (QUC24_20755) 4490346..4491707 - 1362 WP_073647918.1 DNA recombination protein RmuC -
QUC24_RS20760 (QUC24_20760) 4492478..4493233 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QUC24_RS20765 (QUC24_20765) 4493368..4493736 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QUC24_RS20770 (QUC24_20770) 4493809..4495095 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
QUC24_RS20775 (QUC24_20775) 4495151..4496644 - 1494 WP_015648322.1 aldehyde dehydrogenase family protein -
QUC24_RS20780 (QUC24_20780) 4496819..4497295 + 477 WP_004353334.1 elongation factor GreAB -
QUC24_RS20785 (QUC24_20785) 4497298..4497573 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T284674 WP_003086331.1 NZ_CP128506:c4493233-4492478 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT284674 WP_003086329.1 NZ_CP128506:c4493736-4493368 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References