Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3560078..3561299 Replicon chromosome
Accession NZ_CP128506
Organism Pseudomonas aeruginosa strain Fe11-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag QUC24_RS16385 Protein ID WP_003102740.1
Coordinates 3560721..3561299 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QUC24_RS16380 Protein ID WP_003088112.1
Coordinates 3560078..3560632 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC24_RS16355 (QUC24_16355) 3555646..3556197 + 552 WP_003102727.1 XRE family transcriptional regulator -
QUC24_RS16360 (QUC24_16360) 3556194..3556592 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
QUC24_RS16365 (QUC24_16365) 3556605..3556928 - 324 WP_023119961.1 multidrug efflux SMR transporter -
QUC24_RS16370 (QUC24_16370) 3557259..3557720 + 462 Protein_3239 (2Fe-2S)-binding protein -
QUC24_RS16375 (QUC24_16375) 3557725..3559920 + 2196 WP_289393592.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QUC24_RS16380 (QUC24_16380) 3560078..3560632 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QUC24_RS16385 (QUC24_16385) 3560721..3561299 + 579 WP_003102740.1 HD domain-containing protein Toxin
QUC24_RS16390 (QUC24_16390) 3561408..3562595 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
QUC24_RS16395 (QUC24_16395) 3562585..3564756 - 2172 WP_196624046.1 type I secretion system permease/ATPase -
QUC24_RS16400 (QUC24_16400) 3564746..3566023 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T284673 WP_003102740.1 NZ_CP128506:3560721-3561299 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT284673 WP_003088112.1 NZ_CP128506:3560078-3560632 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References