Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 158684..159189 Replicon chromosome
Accession NZ_CP128506
Organism Pseudomonas aeruginosa strain Fe11-1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QUC24_RS00750 Protein ID WP_003083773.1
Coordinates 158684..158965 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QUC24_RS00755 Protein ID WP_003083775.1
Coordinates 158962..159189 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC24_RS00725 (QUC24_00725) 153935..155284 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
QUC24_RS00730 (QUC24_00730) 155333..156019 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QUC24_RS00735 (QUC24_00735) 156120..156854 + 735 WP_003117208.1 GntR family transcriptional regulator -
QUC24_RS00740 (QUC24_00740) 157034..157444 + 411 WP_003101225.1 aegerolysin family protein -
QUC24_RS00745 (QUC24_00745) 157476..158384 - 909 WP_003083769.1 LysR family transcriptional regulator -
QUC24_RS00750 (QUC24_00750) 158684..158965 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QUC24_RS00755 (QUC24_00755) 158962..159189 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QUC24_RS00760 (QUC24_00760) 159365..159985 - 621 WP_003101226.1 hypothetical protein -
QUC24_RS00765 (QUC24_00765) 160086..160586 + 501 WP_003112629.1 LEA type 2 family protein -
QUC24_RS00770 (QUC24_00770) 160659..161000 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QUC24_RS00775 (QUC24_00775) 161082..162509 - 1428 WP_031630494.1 GABA permease -
QUC24_RS00780 (QUC24_00780) 162678..164171 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T284671 WP_003083773.1 NZ_CP128506:c158965-158684 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT284671 WP_003083775.1 NZ_CP128506:c159189-158962 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References