Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4485765..4487023 Replicon chromosome
Accession NZ_CP128505
Organism Pseudomonas aeruginosa strain Fe8-1

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QUC25_RS20690 Protein ID WP_003086331.1
Coordinates 4485765..4486520 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QUC25_RS20695 Protein ID WP_003086329.1
Coordinates 4486655..4487023 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC25_RS20680 (QUC25_20680) 4480935..4483478 + 2544 WP_121196354.1 acyl-homoserine-lactone acylase QuiP -
QUC25_RS20685 (QUC25_20685) 4483633..4484994 - 1362 WP_121196382.1 DNA recombination protein RmuC -
QUC25_RS20690 (QUC25_20690) 4485765..4486520 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QUC25_RS20695 (QUC25_20695) 4486655..4487023 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QUC25_RS20700 (QUC25_20700) 4487096..4488382 - 1287 WP_023097911.1 FAD-binding oxidoreductase -
QUC25_RS20705 (QUC25_20705) 4488438..4489931 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QUC25_RS20710 (QUC25_20710) 4490106..4490582 + 477 WP_004353334.1 elongation factor GreAB -
QUC25_RS20715 (QUC25_20715) 4490585..4490740 - 156 WP_015503364.1 zinc ribbon domain-containing protein -
QUC25_RS20720 (QUC25_20720) 4490765..4490899 + 135 WP_023435240.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T284668 WP_003086331.1 NZ_CP128505:c4486520-4485765 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT284668 WP_003086329.1 NZ_CP128505:c4487023-4486655 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References