Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1858586..1860094 Replicon chromosome
Accession NZ_CP128505
Organism Pseudomonas aeruginosa strain Fe8-1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QUC25_RS08680 Protein ID WP_289344519.1
Coordinates 1858586..1859173 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag QUC25_RS08685 Protein ID WP_003091607.1
Coordinates 1859240..1860094 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC25_RS08675 (QUC25_08675) 1854841..1858320 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QUC25_RS08680 (QUC25_08680) 1858586..1859173 + 588 WP_289344519.1 GNAT family protein Toxin
QUC25_RS08685 (QUC25_08685) 1859240..1860094 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
QUC25_RS08690 (QUC25_08690) 1860191..1862356 + 2166 WP_023097365.1 TonB-dependent receptor family protein -
QUC25_RS08695 (QUC25_08695) 1862531..1864405 + 1875 WP_003091605.1 MFS transporter -
QUC25_RS08700 (QUC25_08700) 1864466..1864675 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21958.28 Da        Isoelectric Point: 9.8676

>T284666 WP_289344519.1 NZ_CP128505:1858586-1859173 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAANNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKATLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT284666 WP_003091607.1 NZ_CP128505:1859240-1860094 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References