Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150641..151146 Replicon chromosome
Accession NZ_CP128505
Organism Pseudomonas aeruginosa strain Fe8-1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QUC25_RS00700 Protein ID WP_003083773.1
Coordinates 150641..150922 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag QUC25_RS00705 Protein ID WP_003137009.1
Coordinates 150919..151146 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC25_RS00675 (QUC25_00675) 145892..147241 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
QUC25_RS00680 (QUC25_00680) 147290..147976 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QUC25_RS00685 (QUC25_00685) 148077..148811 + 735 WP_003110658.1 GntR family transcriptional regulator -
QUC25_RS00690 (QUC25_00690) 148991..149401 + 411 WP_003110659.1 aegerolysin family protein -
QUC25_RS00695 (QUC25_00695) 149433..150341 - 909 WP_003083769.1 LysR family transcriptional regulator -
QUC25_RS00700 (QUC25_00700) 150641..150922 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QUC25_RS00705 (QUC25_00705) 150919..151146 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
QUC25_RS00710 (QUC25_00710) 151322..151942 - 621 WP_023092259.1 hypothetical protein -
QUC25_RS00715 (QUC25_00715) 152043..152543 + 501 WP_003101228.1 LEA type 2 family protein -
QUC25_RS00720 (QUC25_00720) 152616..152957 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QUC25_RS00725 (QUC25_00725) 153039..154466 - 1428 WP_003083784.1 GABA permease -
QUC25_RS00730 (QUC25_00730) 154635..156128 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T284665 WP_003083773.1 NZ_CP128505:c150922-150641 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT284665 WP_003137009.1 NZ_CP128505:c151146-150919 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References