Detailed information of TA system TA028466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2882618..2883258
• Replicon: chromosome
• Accession: NC_019395
• Organism: Propionibacterium acidipropionici ATCC 4875

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: K7RZN5
• Locus tag: PACID_RS13390
• Protein ID: WP_015071400.1
• Coordinates: 2882866..2883258 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K7S7C8
• Locus tag: PACID_RS13385
• Protein ID: WP_015071399.1
• Coordinates: 2882618..2882869 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PACID_RS13370	2878554..2879486	+	933	WP_015071395.1	hydrogen peroxide-inducible genes activator	-
PACID_RS13375	2879589..2881022	-	1434	WP_015071396.1	adenylosuccinate lyase	-
PACID_RS13380	2881084..2882403	-	1320	WP_028700705.1	phosphoribosylamine--glycine ligase	-
PACID_RS13385	2882618..2882869	+	252	WP_015071399.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
PACID_RS13390	2882866..2883258	+	393	WP_015071400.1	type II toxin-antitoxin system VapC family toxin	Toxin
PACID_RS13395	2883460..2884746	-	1287	WP_015071401.1	adenylosuccinate synthase	-
PACID_RS13400	2884951..2885817	-	867	WP_015071402.1	GNAT family N-acetyltransferase	-
PACID_RS13405	2885878..2886579	-	702	WP_015071403.1	DUF3151 family protein	-
PACID_RS13410	2886731..2887021	+	291	WP_148279567.1	metal-sensitive transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13574.31 Da
• Isoelectric Point: 3.9588

>T28466 WP_015071400.1 NC_019395:2882866-2883258 [Acidipropionibacterium acidipropionici ATCC 4875]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAA
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDDFPQTDIVVADR

Nucleotide

• Length: 393 bp

>T28466 NC_019395:2882866-2883258 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGCT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGACTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.56 Da
• Isoelectric Point: 6.0829

>AT28466 WP_015071399.1 NC_019395:2882618-2882869 [Acidipropionibacterium acidipropionici ATCC 4875]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Nucleotide

• Length: 252 bp

>AT28466 NC_019395:2882618-2882869 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Structures

Toxin

• AlphaFold DB: K7RZN5

Antitoxin

• AlphaFold DB: K7S7C8