284651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 800757..801561 Replicon chromosome
Accession NZ_CP128494
Organism Geobacillus stearothermophilus ATCC 12980

Toxin (Protein)


Gene name hepT Uniprot ID G8MYR9
Locus tag QSJ10_RS04350 Protein ID WP_014195290.1
Coordinates 800757..801176 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag QSJ10_RS04355 Protein ID WP_031212949.1
Coordinates 801166..801561 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSJ10_RS04330 (QSJ10_04330) 797666..798184 + 519 WP_033015854.1 GNAT family N-acetyltransferase -
QSJ10_RS04335 (QSJ10_04335) 798314..799042 + 729 WP_033015856.1 ABC transporter ATP-binding protein -
QSJ10_RS04340 (QSJ10_04340) 799039..800064 + 1026 WP_033015858.1 ABC transporter permease -
QSJ10_RS04345 (QSJ10_04345) 800076..800729 + 654 WP_033015860.1 TetR/AcrR family transcriptional regulator -
QSJ10_RS04350 (QSJ10_04350) 800757..801176 - 420 WP_014195290.1 DUF86 domain-containing protein Toxin
QSJ10_RS04355 (QSJ10_04355) 801166..801561 - 396 WP_031212949.1 nucleotidyltransferase domain-containing protein Antitoxin
QSJ10_RS04360 (QSJ10_04360) 801868..804000 - 2133 WP_033015862.1 ATP-dependent Clp protease ATP-binding subunit -
QSJ10_RS04365 (QSJ10_04365) 804268..805014 + 747 WP_033015863.1 FixH family protein -
QSJ10_RS04370 (QSJ10_04370) 805183..806220 + 1038 WP_183084019.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - clpE 798314..824656 26342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(5-94)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15907.43 Da        Isoelectric Point: 8.2859

>T284651 WP_014195290.1 NZ_CP128494:c801176-800757 [Geobacillus stearothermophilus ATCC 12980]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS

Download         Length: 420 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14797.97 Da        Isoelectric Point: 5.6982

>AT284651 WP_031212949.1 NZ_CP128494:c801561-801166 [Geobacillus stearothermophilus ATCC 12980]
METIIIQTLRPALHPFVIYLFGSAARGAMRPDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQASTVFQA
QVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8MYR9

Antitoxin

Source ID Structure

References