Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | doc-NpoA/Fic(toxin) |
| Location | 575040..576398 | Replicon | chromosome |
| Accession | NZ_CP128494 | ||
| Organism | Geobacillus stearothermophilus ATCC 12980 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A150MRT2 |
| Locus tag | QSJ10_RS03150 | Protein ID | WP_033013801.1 |
| Coordinates | 576006..576398 (-) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | NpoA | Uniprot ID | A0A150MRR6 |
| Locus tag | QSJ10_RS03145 | Protein ID | WP_033013802.1 |
| Coordinates | 575040..575903 (-) | Length | 288 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QSJ10_RS03120 (QSJ10_03120) | 570564..572099 | + | 1536 | WP_033013805.1 | alpha-amylase family glycosyl hydrolase | - |
| QSJ10_RS03125 (QSJ10_03125) | 572118..573137 | + | 1020 | WP_053532441.1 | LacI family DNA-binding transcriptional regulator | - |
| QSJ10_RS03130 (QSJ10_03130) | 573122..574075 | + | 954 | WP_230847123.1 | efflux RND transporter periplasmic adaptor subunit | - |
| QSJ10_RS03135 (QSJ10_03135) | 574072..574278 | + | 207 | WP_033013803.1 | ATP-binding protein | - |
| QSJ10_RS03140 (QSJ10_03140) | 574577..574750 | + | 174 | WP_147432141.1 | aromatic acid/H+ symport family MFS transporter | - |
| QSJ10_RS03145 (QSJ10_03145) | 575040..575903 | - | 864 | WP_033013802.1 | SDR family oxidoreductase | Antitoxin |
| QSJ10_RS03150 (QSJ10_03150) | 576006..576398 | - | 393 | WP_033013801.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| QSJ10_RS03155 (QSJ10_03155) | 576411..576683 | - | 273 | WP_033013800.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| QSJ10_RS03160 (QSJ10_03160) | 576833..580243 | - | 3411 | WP_053532440.1 | methionine synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14980.35 Da Isoelectric Point: 8.8161
>T284650 WP_033013801.1 NZ_CP128494:c576398-576006 [Geobacillus stearothermophilus ATCC 12980]
MTRFLTEKEIIFLNALLIEKYTPEEQKGVKFPELLNSAVNRPKQSAFGQDAYPTLWLKAAALYASLCQNHPFHNANKRTG
FAAMKQFLWLNGYLLAAPEKEAEEYTVKVVTDKPSIEEIAMWIETWAKKR
MTRFLTEKEIIFLNALLIEKYTPEEQKGVKFPELLNSAVNRPKQSAFGQDAYPTLWLKAAALYASLCQNHPFHNANKRTG
FAAMKQFLWLNGYLLAAPEKEAEEYTVKVVTDKPSIEEIAMWIETWAKKR
Download Length: 393 bp
Antitoxin
Download Length: 288 a.a. Molecular weight: 30780.01 Da Isoelectric Point: 7.3723
>AT284650 WP_033013802.1 NZ_CP128494:c575903-575040 [Geobacillus stearothermophilus ATCC 12980]
MVTKQQTTLPPQHQTRQPGLQTEMNPQPVTIKDTYKGSGKLKNKTAIISGGDSGIGRAVAVHFAKEGADVAIIYLNEHED
ADETKRLVEQEGRRCLAIAGDIGDEAFCKEAVKQTIEAFGKLDIVVNNAAEQHPQPNFLNITAAQLEKTFRTNVFGCFFL
TKAALPHLKSGSAIINTASITAYEGNEQLIDYSATKGAIVAFTRSLAKALVGQGIRVNGVAPGPIWTPLIPSTFKSEQVA
TFGANTPMKRPGQPSEVAPCYVFLASDESSYMTGQMLHVDGGKFVSG
MVTKQQTTLPPQHQTRQPGLQTEMNPQPVTIKDTYKGSGKLKNKTAIISGGDSGIGRAVAVHFAKEGADVAIIYLNEHED
ADETKRLVEQEGRRCLAIAGDIGDEAFCKEAVKQTIEAFGKLDIVVNNAAEQHPQPNFLNITAAQLEKTFRTNVFGCFFL
TKAALPHLKSGSAIINTASITAYEGNEQLIDYSATKGAIVAFTRSLAKALVGQGIRVNGVAPGPIWTPLIPSTFKSEQVA
TFGANTPMKRPGQPSEVAPCYVFLASDESSYMTGQMLHVDGGKFVSG
Download Length: 864 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A150MRT2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A150MRR6 |