Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 210500..211136 Replicon chromosome
Accession NZ_CP128494
Organism Geobacillus stearothermophilus ATCC 12980

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag QSJ10_RS01170 Protein ID WP_003253417.1
Coordinates 210786..211136 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A087LE06
Locus tag QSJ10_RS01165 Protein ID WP_033010302.1
Coordinates 210500..210781 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSJ10_RS01145 (QSJ10_01145) 206750..207367 - 618 WP_053532150.1 rhomboid family intramembrane serine protease -
QSJ10_RS01150 (QSJ10_01150) 207486..207875 + 390 WP_033010299.1 holo-ACP synthase -
QSJ10_RS01155 (QSJ10_01155) 207956..208975 + 1020 WP_033016553.1 outer membrane lipoprotein carrier protein LolA -
QSJ10_RS01160 (QSJ10_01160) 209219..210385 + 1167 WP_053532153.1 alanine racemase -
QSJ10_RS01165 (QSJ10_01165) 210500..210781 + 282 WP_033010302.1 hypothetical protein Antitoxin
QSJ10_RS01170 (QSJ10_01170) 210786..211136 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QSJ10_RS01175 (QSJ10_01175) 211679..213841 + 2163 WP_049624463.1 Tex family protein -
QSJ10_RS01180 (QSJ10_01180) 213899..214012 - 114 WP_121625977.1 cortex morphogenetic protein CmpA -
QSJ10_RS01185 (QSJ10_01185) 214106..214567 + 462 WP_033016555.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T284649 WP_003253417.1 NZ_CP128494:210786-211136 [Geobacillus stearothermophilus ATCC 12980]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10683.20 Da        Isoelectric Point: 7.2027

>AT284649 WP_033010302.1 NZ_CP128494:210500-210781 [Geobacillus stearothermophilus ATCC 12980]
VSESGATTEIIVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A087LE06

References