Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 396744..397357 Replicon plasmid pHR1a
Accession NZ_CP128493
Organism Novosphingobium resinovorum strain HR1a

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag QUC32_RS28745 Protein ID WP_211152191.1
Coordinates 397070..397357 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1D8AFB2
Locus tag QUC32_RS28740 Protein ID WP_069710097.1
Coordinates 396744..397031 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC32_RS28715 (QUC32_28715) 392071..393453 + 1383 WP_289357792.1 hypothetical protein -
QUC32_RS28720 (QUC32_28720) 393468..394001 - 534 WP_211152190.1 hypothetical protein -
QUC32_RS28725 (QUC32_28725) 394728..394952 - 225 WP_069710095.1 hypothetical protein -
QUC32_RS28730 (QUC32_28730) 395354..395779 + 426 WP_069710096.1 hypothetical protein -
QUC32_RS28735 (QUC32_28735) 395965..396285 - 321 WP_008832418.1 DUF736 family protein -
QUC32_RS28740 (QUC32_28740) 396744..397031 - 288 WP_069710097.1 putative addiction module antidote protein Antitoxin
QUC32_RS28745 (QUC32_28745) 397070..397357 - 288 WP_211152191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUC32_RS28750 (QUC32_28750) 397602..399431 - 1830 WP_211152192.1 ParB/RepB/Spo0J family partition protein -
QUC32_RS28755 (QUC32_28755) 399523..399903 - 381 WP_231958527.1 DUF2958 domain-containing protein -
QUC32_RS28760 (QUC32_28760) 399930..400949 - 1020 WP_211152193.1 zincin-like metallopeptidase domain-containing protein -
QUC32_RS28765 (QUC32_28765) 401471..401845 + 375 WP_248006466.1 thermonuclease family protein -
QUC32_RS28770 (QUC32_28770) 402126..402290 + 165 WP_156800016.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / katA 1..819262 819262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-95)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10689.23 Da        Isoelectric Point: 10.4170

>T284648 WP_211152191.1 NZ_CP128493:c397357-397070 [Novosphingobium resinovorum]
MEVTQTAVFAQWFHRLRDPKAQSRIAQRIARIEIGLMGDVKSVGDGVSEARIDYGPGYRLYFTRRGDELVILLVGGDKSS
QQRDIARARQLAAQL

Download         Length: 288 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10256.91 Da        Isoelectric Point: 6.4632

>AT284648 WP_069710097.1 NZ_CP128493:c397031-396744 [Novosphingobium resinovorum]
MTIELTRFDAATYLTQPEDQAQLLAAAVESGDPHIVAKAIGIVARAHGMTELARETGMKRQQLYRALGPDGNPTLETMLK
VLPALGLRMRIEAAA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8AFB2

References