Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5208787..5209412 Replicon chromosome
Accession NZ_CP128487
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag QTN20_RS27530 Protein ID WP_004187928.1
Coordinates 5208787..5209170 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QTN20_RS27535 Protein ID WP_004150355.1
Coordinates 5209170..5209412 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN20_RS27515 (5206153) 5206153..5207055 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QTN20_RS27520 (5207052) 5207052..5207687 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QTN20_RS27525 (5207684) 5207684..5208613 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QTN20_RS27530 (5208787) 5208787..5209170 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
QTN20_RS27535 (5209170) 5209170..5209412 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QTN20_RS27540 (5209606) 5209606..5210523 + 918 WP_032437488.1 alpha/beta hydrolase -
QTN20_RS27545 (5210537) 5210537..5211478 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QTN20_RS27550 (5211523) 5211523..5211960 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QTN20_RS27555 (5211957) 5211957..5212817 - 861 WP_004146232.1 virulence factor BrkB family protein -
QTN20_RS27560 (5212811) 5212811..5213410 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T284645 WP_004187928.1 NZ_CP128487:c5209170-5208787 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT284645 WP_004150355.1 NZ_CP128487:c5209412-5209170 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References