Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4886372..4888053 Replicon chromosome
Accession NZ_CP128487
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag QTN20_RS26045 Protein ID WP_002885155.1
Coordinates 4886372..4887289 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag QTN20_RS26050 Protein ID WP_004192584.1
Coordinates 4887295..4888053 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN20_RS26025 (4881678) 4881678..4883198 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
QTN20_RS26030 (4883195) 4883195..4884193 + 999 WP_002885172.1 ribose ABC transporter permease -
QTN20_RS26035 (4884224) 4884224..4885165 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QTN20_RS26040 (4885240) 4885240..4886247 + 1008 WP_004177805.1 carbohydrate kinase family protein -
QTN20_RS26045 (4886372) 4886372..4887289 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QTN20_RS26050 (4887295) 4887295..4888053 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QTN20_RS26055 (4888139) 4888139..4888867 - 729 WP_002885152.1 response regulator transcription factor -
QTN20_RS26060 (4889140) 4889140..4891287 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
QTN20_RS26065 (4891517) 4891517..4892203 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T284644 WP_002885155.1 NZ_CP128487:c4887289-4886372 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT284644 WP_004192584.1 NZ_CP128487:c4888053-4887295 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References