Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4720199..4720715 Replicon chromosome
Accession NZ_CP128487
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag QTN20_RS25210 Protein ID WP_004192395.1
Coordinates 4720199..4720483 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag QTN20_RS25215 Protein ID WP_004192397.1
Coordinates 4720473..4720715 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN20_RS25185 (4715616) 4715616..4715879 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QTN20_RS25190 (4716009) 4716009..4716182 + 174 WP_002886906.1 hypothetical protein -
QTN20_RS25195 (4716185) 4716185..4716928 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QTN20_RS25200 (4717285) 4717285..4719423 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QTN20_RS25205 (4719731) 4719731..4720195 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QTN20_RS25210 (4720199) 4720199..4720483 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QTN20_RS25215 (4720473) 4720473..4720715 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QTN20_RS25220 (4720793) 4720793..4722703 - 1911 WP_004152270.1 PRD domain-containing protein -
QTN20_RS25225 (4722726) 4722726..4723880 - 1155 WP_004178372.1 lactonase family protein -
QTN20_RS25230 (4723947) 4723947..4724687 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T284643 WP_004192395.1 NZ_CP128487:c4720483-4720199 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT284643 WP_004192397.1 NZ_CP128487:c4720715-4720473 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References