Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4597331..4598141 Replicon chromosome
Accession NZ_CP128487
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name KacT Uniprot ID A0A483G813
Locus tag QTN20_RS24610 Protein ID WP_023279404.1
Coordinates 4597331..4597864 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QTN20_RS24615 Protein ID WP_002887278.1
Coordinates 4597875..4598141 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN20_RS24605 (4596162) 4596162..4597283 + 1122 WP_002887282.1 cupin domain-containing protein -
QTN20_RS24610 (4597331) 4597331..4597864 - 534 WP_023279404.1 type II toxin-antitoxin system toxin KacT Toxin
QTN20_RS24615 (4597875) 4597875..4598141 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QTN20_RS24620 (4598244) 4598244..4599677 - 1434 WP_004192214.1 Cu(+)/Ag(+) sensor histidine kinase -
QTN20_RS24625 (4599667) 4599667..4600350 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QTN20_RS24630 (4600522) 4600522..4601907 + 1386 WP_004192218.1 efflux transporter outer membrane subunit -
QTN20_RS24635 (4601925) 4601925..4602269 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19809.71 Da        Isoelectric Point: 6.2369

>T284642 WP_023279404.1 NZ_CP128487:c4597864-4597331 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDKNSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT284642 WP_002887278.1 NZ_CP128487:c4598141-4597875 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483G813

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References