Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2635723..2637311 Replicon chromosome
Accession NZ_CP128487
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag QTN20_RS14935 Protein ID WP_004190166.1
Coordinates 2635723..2637045 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QTN20_RS14940 Protein ID WP_002904790.1
Coordinates 2637045..2637311 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN20_RS14920 (2630779) 2630779..2633280 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
QTN20_RS14925 (2633268) 2633268..2634272 + 1005 WP_004190163.1 fimbrial protein -
QTN20_RS14930 (2634414) 2634414..2635706 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QTN20_RS14935 (2635723) 2635723..2637045 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
QTN20_RS14940 (2637045) 2637045..2637311 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QTN20_RS14945 (2637576) 2637576..2637902 - 327 WP_004143476.1 hydroxyisourate hydrolase -
QTN20_RS14950 (2637899) 2637899..2638399 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QTN20_RS14955 (2638377) 2638377..2639756 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QTN20_RS14960 (2640102) 2640102..2641256 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QTN20_RS14965 (2641237) 2641237..2642160 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T284640 WP_004190166.1 NZ_CP128487:c2637045-2635723 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT284640 WP_002904790.1 NZ_CP128487:c2637311-2637045 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References