Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 90298..91208 Replicon plasmid pYZEF2-2C_tmex
Accession NZ_CP128484
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QTN20_RS00465 Protein ID WP_032413375.1
Coordinates 90298..90768 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7H4PRG4
Locus tag QTN20_RS00470 Protein ID WP_032413443.1
Coordinates 90765..91208 (-) Length 148 a.a.

Genomic Context


QTN20_RS00430QTN20_RS00435QTN20_RS00455QTN20_RS00460QTN20_RS00485QTN20_RS00495QTN20_RS00500QTN20_RS00425QTN20_RS00440QTN20_RS00445QTN20_RS00450QTN20_RS00465QTN20_RS00470QTN20_RS00475QTN20_RS00480QTN20_RS00490
Location: 86177..86269 (93 bp)
Type: Others
Protein ID: Protein_85
Location: 87005..87160 (156 bp)
Type: Others
Protein ID: Protein_86
Location: 88979..89356 (378 bp)
Type: Others
Protein ID: Protein_90
Location: 89928..90188 (261 bp)
Type: Others
Protein ID: WP_017901409.1
Location: 92126..92707 (582 bp)
Type: Others
Protein ID: WP_077254766.1
Location: 93794..94762 (969 bp)
Type: Others
Protein ID: WP_077268726.1
Location: 94853..95524 (672 bp)
Type: Others
Protein ID: WP_159226239.1
Location: 85599..86135 (537 bp)
Type: Others
Protein ID: WP_032437437.1
Location: 87101..87628 (528 bp)
Type: Others
Protein ID: WP_224707344.1
Location: 87639..88589 (951 bp)
Type: Others
Protein ID: WP_077268727.1
Location: 88712..88905 (194 bp)
Type: Others
Protein ID: Protein_89
Location: 90298..90768 (471 bp)
Type: Toxin
Protein ID: WP_032413375.1
Location: 90765..91208 (444 bp)
Type: Antitoxin
Protein ID: WP_032413443.1
Location: 91308..91820 (513 bp)
Type: Others
Protein ID: Protein_94
Location: 91921..92106 (186 bp)
Type: Others
Protein ID: WP_071571073.1
Location: 92830..93378 (549 bp)
Type: Others
Protein ID: WP_023320124.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QTN20_RS00425 (QTN20_00425)85599..86135-537WP_032437437.1hypothetical protein-
QTN20_RS00430 (QTN20_00430)86177..86269+93Protein_85hypothetical protein-
QTN20_RS00435 (QTN20_00435)87005..87160+156Protein_86transposase-
QTN20_RS00440 (QTN20_00440)87101..87628-528WP_224707344.1hypothetical protein-
QTN20_RS00445 (QTN20_00445)87639..88589-951WP_077268727.1IS5-like element IS903B family transposase-
QTN20_RS00450 (QTN20_00450)88712..88905-194Protein_89transposase-
QTN20_RS00455 (QTN20_00455)88979..89356+378Protein_90integrase core domain-containing protein-
QTN20_RS00460 (QTN20_00460)89928..90188+261WP_017901409.1hypothetical protein-
QTN20_RS00465 (QTN20_00465)90298..90768-471WP_032413375.1RES family NAD+ phosphorylaseToxin
QTN20_RS00470 (QTN20_00470)90765..91208-444WP_032413443.1DUF2384 domain-containing proteinAntitoxin
QTN20_RS00475 (QTN20_00475)91308..91820-513Protein_94DUF4113 domain-containing protein-
QTN20_RS00480 (QTN20_00480)91921..92106-186WP_071571073.1DUF2188 domain-containing protein-
QTN20_RS00485 (QTN20_00485)92126..92707+582WP_077254766.1transposase-
QTN20_RS00490 (QTN20_00490)92830..93378-549WP_023320124.1GNAT family N-acetyltransferase-
QTN20_RS00495 (QTN20_00495)93794..94762+969WP_077268726.1IS5-like element IS903B family transposase-
QTN20_RS00500 (QTN20_00500)94853..95524+672WP_159226239.1alpha/beta hydrolase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaph(3'')-Ib / aph(6)-Id / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2-1..207962207962
-insideIScluster/Tn--83120..10998526865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-148)

Antitoxin

(16-147)


Sequences


Toxin        


Download         Length: 157 a.a.        Molecular weight: 17547.79 Da        Isoelectric Point: 4.5152

>T284631 WP_032413375.1 NZ_CP128484:c90768-90298 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIAFRFDSRLKPDRK

Download         Length: 471 bp


Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16508.82 Da        Isoelectric Point: 10.3013

>AT284631 WP_032413443.1 NZ_CP128484:c91208-90765 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7H4PRG4

References