Detailed information of TA system TA028463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 29133..29815
• Replicon: chromosome
• Accession: NC_019395
• Organism: Propionibacterium acidipropionici ATCC 4875

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PACID_RS00135
• Protein ID: WP_015068796.1
• Coordinates: 29133..29552 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K7SF30
• Locus tag: PACID_RS00140
• Protein ID: WP_015068797.1
• Coordinates: 29552..29815 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PACID_RS00090	24138..24521	+	384	WP_015068789.1	D-ribose pyranase	-
PACID_RS00095	24539..25300	-	762	WP_015068790.1	ABC transporter permease	-
PACID_RS00100	25297..26100	-	804	WP_015068791.1	ATP-binding cassette domain-containing protein	-
PACID_RS00105	26097..26504	-	408	WP_126133026.1	DUF1048 domain-containing protein	-
PACID_RS00110	26504..26821	-	318	WP_198027931.1	PadR family transcriptional regulator	-
PACID_RS00115	26983..27900	-	918	WP_015068794.1	SDR family oxidoreductase	-
PACID_RS00125	28293..28660	+	368	Protein_23	type II toxin-antitoxin system RelE/ParE family toxin	-
PACID_RS00130	28666..28971	+	306	WP_041707669.1	helix-turn-helix domain-containing protein	-
PACID_RS00135	29133..29552	-	420	WP_015068796.1	type II toxin-antitoxin system VapC family toxin	Toxin
PACID_RS00140	29552..29815	-	264	WP_015068797.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PACID_RS18300	29937..30086	-	150	WP_160165413.1	hypothetical protein	-
PACID_RS00150	30433..30882	+	450	WP_015068799.1	CBS domain-containing protein	-
PACID_RS00155	30935..32227	+	1293	WP_041707670.1	ArsB/NhaD family transporter	-
PACID_RS00160	32291..33589	-	1299	WP_015068801.1	MFS transporter	-
PACID_RS00165	33859..34668	-	810	WP_015068802.1	tyrosine-protein phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-41)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15077.34 Da
• Isoelectric Point: 4.9147

>T28463 WP_015068796.1 NC_019395:c29552-29133 [Acidipropionibacterium acidipropionici ATCC 4875]
MFYADTSALVKLVVIEPESGALLDWLGHRDASLATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVVAPGTPRNPQPNII

Nucleotide

• Length: 420 bp

>T28463 NC_019395:c29552-29133 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCTCCCTGGCGACCAGCGACCTTGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACTGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGTCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9390.67 Da
• Isoelectric Point: 10.3568

>AT28463 WP_015068797.1 NC_019395:c29815-29552 [Acidipropionibacterium acidipropionici ATCC 4875]
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY

Nucleotide

• Length: 264 bp

>AT28463 NC_019395:c29815-29552 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA

Structures

Antitoxin

• AlphaFold DB: K7SF30