Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1821719..1822204 Replicon chromosome
Accession NZ_CP128470
Organism Macrococcus bovicus strain LI0213

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QSV55_RS09940 Protein ID WP_133452080.1
Coordinates 1821719..1822060 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QSV55_RS09945 Protein ID WP_165983752.1
Coordinates 1822061..1822204 (-) Length 48 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV55_RS09915 (QSV55_09940) 1816800..1818944 - 2145 WP_289650068.1 Tex family protein -
QSV55_RS09920 (QSV55_09945) 1819007..1819783 - 777 WP_133452084.1 RNA polymerase sigma factor SigB -
QSV55_RS09925 (QSV55_09950) 1819758..1820231 - 474 WP_133452083.1 anti-sigma B factor RsbW -
QSV55_RS09930 (QSV55_09955) 1820233..1820556 - 324 WP_133452082.1 anti-sigma factor antagonist -
QSV55_RS09935 (QSV55_09960) 1820645..1821643 - 999 WP_289651073.1 PP2C family protein-serine/threonine phosphatase -
QSV55_RS09940 (QSV55_09965) 1821719..1822060 - 342 WP_133452080.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QSV55_RS09945 (QSV55_09970) 1822061..1822204 - 144 WP_165983752.1 hypothetical protein Antitoxin
QSV55_RS09950 (QSV55_09975) 1822264..1823394 - 1131 WP_289650069.1 alanine racemase -
QSV55_RS09955 (QSV55_09980) 1823408..1823755 - 348 WP_289650070.1 holo-ACP synthase -
QSV55_RS09960 (QSV55_09985) 1823752..1824225 - 474 WP_289650071.1 PH domain-containing protein -
QSV55_RS09965 (QSV55_09990) 1824212..1825684 - 1473 WP_289650072.1 PH domain-containing protein -
QSV55_RS09970 (QSV55_09995) 1825677..1826153 - 477 WP_289650073.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12436.45 Da        Isoelectric Point: 10.0504

>T284626 WP_133452080.1 NZ_CP128470:c1822060-1821719 [Macrococcus bovicus]
MRRGEVFLADLSPVKGSEQGGKRPVVIIQNDVGNKYSPTVIVAAITAKINKARIPTHVEIGKTNHHLDKDSVILLEQIRT
IDKNRLIEKLTVLSEEKMSEVNQALAISLGLSQ

Download         Length: 342 bp

Antitoxin


Download         Length: 48 a.a.        Molecular weight: 5471.04 Da        Isoelectric Point: 3.5509

>AT284626 WP_165983752.1 NZ_CP128470:c1822204-1822061 [Macrococcus bovicus]
MKKFDQLLAEGYESMAELNLIISYEQFDLESEVCEKSEMYDLADDGE

Download         Length: 144 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References