Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5430795..5431420 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name vapC Uniprot ID A0A1F2M041
Locus tag QSV42_RS26775 Protein ID WP_008807903.1
Coordinates 5430795..5431178 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QSV42_RS26780 Protein ID WP_004150355.1
Coordinates 5431178..5431420 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS26760 (QSV42_26755) 5428161..5429063 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QSV42_RS26765 (QSV42_26760) 5429060..5429695 + 636 WP_008807902.1 formate dehydrogenase cytochrome b556 subunit -
QSV42_RS26770 (QSV42_26765) 5429692..5430621 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QSV42_RS26775 (QSV42_26770) 5430795..5431178 - 384 WP_008807903.1 type II toxin-antitoxin system VapC family toxin Toxin
QSV42_RS26780 (QSV42_26775) 5431178..5431420 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QSV42_RS26785 (QSV42_26780) 5431625..5432542 + 918 WP_048964069.1 alpha/beta hydrolase -
QSV42_RS26790 (QSV42_26785) 5432557..5433498 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
QSV42_RS26795 (QSV42_26790) 5433543..5433980 - 438 WP_012543288.1 D-aminoacyl-tRNA deacylase -
QSV42_RS26800 (QSV42_26795) 5433977..5434837 - 861 WP_008807907.1 virulence factor BrkB family protein -
QSV42_RS26805 (QSV42_26800) 5434831..5435430 - 600 WP_008807908.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T284624 WP_008807903.1 NZ_CP128466:c5431178-5430795 [Klebsiella variicola]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYELHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT284624 WP_004150355.1 NZ_CP128466:c5431420-5431178 [Klebsiella variicola]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2M041

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References