Detailed information of TA system TA284623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5106250..5107931
• Replicon: chromosome
• Accession: NZ_CP128466
• Organism: Klebsiella variicola strain 22KM2707

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: QSV42_RS25275
• Protein ID: WP_094917989.1
• Coordinates: 5106250..5107167 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: QSV42_RS25280
• Protein ID: WP_008807257.1
• Coordinates: 5107173..5107931 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QSV42_RS25255 (QSV42_25250)	5101557..5103077	+	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-
QSV42_RS25260 (QSV42_25255)	5103074..5104072	+	999	WP_004206363.1	ribose ABC transporter permease	-
QSV42_RS25265 (QSV42_25260)	5104103..5105044	+	942	WP_008807254.1	ABC transporter substrate-binding protein	-
QSV42_RS25270 (QSV42_25265)	5105119..5106126	+	1008	WP_023339423.1	carbohydrate kinase family protein	-
QSV42_RS25275 (QSV42_25270)	5106250..5107167	-	918	WP_094917989.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QSV42_RS25280 (QSV42_25275)	5107173..5107931	-	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
QSV42_RS25285 (QSV42_25280)	5108016..5108744	-	729	WP_008807258.1	response regulator transcription factor	-
QSV42_RS25290 (QSV42_25285)	5109017..5111164	+	2148	WP_077598880.1	formate dehydrogenase subunit alpha	-
QSV42_RS25295 (QSV42_25290)	5111518..5112204	+	687	WP_008807260.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34706.14 Da
• Isoelectric Point: 5.4707

>T284623 WP_094917989.1 NZ_CP128466:c5107167-5106250 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQLQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT284623 WP_008807257.1 NZ_CP128466:c5107931-5107173 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A0A0B7GCX3