Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4941715..4942231 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QSV42_RS24460 Protein ID WP_022065401.1
Coordinates 4941715..4941999 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QSV42_RS24465 Protein ID WP_002886901.1
Coordinates 4941989..4942231 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS24445 (QSV42_24440) 4936818..4938473 + 1656 WP_038422038.1 alpha,alpha-phosphotrehalase -
QSV42_RS24450 (QSV42_24445) 4938859..4940997 + 2139 WP_044614392.1 anaerobic ribonucleoside-triphosphate reductase -
QSV42_RS24455 (QSV42_24450) 4941247..4941711 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QSV42_RS24460 (QSV42_24455) 4941715..4941999 - 285 WP_022065401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QSV42_RS24465 (QSV42_24460) 4941989..4942231 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QSV42_RS24470 (QSV42_24465) 4942309..4944219 - 1911 WP_032756354.1 PRD domain-containing protein -
QSV42_RS24475 (QSV42_24470) 4944242..4945396 - 1155 WP_070612160.1 lactonase family protein -
QSV42_RS24480 (QSV42_24475) 4945491..4946231 - 741 WP_008807137.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11128.97 Da        Isoelectric Point: 10.2849

>T284622 WP_022065401.1 NZ_CP128466:c4941999-4941715 [Klebsiella variicola]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT284622 WP_002886901.1 NZ_CP128466:c4942231-4941989 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References