Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4829314..4829890 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag QSV42_RS23965 Protein ID WP_012542979.1
Coordinates 4829603..4829890 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag QSV42_RS23960 Protein ID WP_022065028.1
Coordinates 4829314..4829616 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS23935 (QSV42_23930) 4824723..4825787 - 1065 WP_008807596.1 DUF2955 domain-containing protein -
QSV42_RS23940 (QSV42_23935) 4825777..4826844 - 1068 WP_064171341.1 HlyD family secretion protein -
QSV42_RS23945 (QSV42_23940) 4826851..4827315 - 465 WP_008807598.1 MarR family transcriptional regulator -
QSV42_RS23950 (QSV42_23945) 4827481..4827645 - 165 WP_008807599.1 DUF1127 domain-containing protein -
QSV42_RS23955 (QSV42_23950) 4827823..4829235 + 1413 WP_008807600.1 PLP-dependent aminotransferase family protein -
QSV42_RS23960 (QSV42_23955) 4829314..4829616 - 303 WP_022065028.1 BrnA antitoxin family protein Antitoxin
QSV42_RS23965 (QSV42_23960) 4829603..4829890 - 288 WP_012542979.1 BrnT family toxin Toxin
QSV42_RS23970 (QSV42_23965) 4830058..4830477 - 420 WP_032740393.1 FosA5 family fosfomycin resistance glutathione transferase -
QSV42_RS23975 (QSV42_23970) 4830471..4831379 - 909 WP_012542980.1 LysR family transcriptional regulator -
QSV42_RS23980 (QSV42_23975) 4831466..4832248 + 783 WP_012542981.1 NAD(P)H-dependent oxidoreductase -
QSV42_RS23985 (QSV42_23980) 4832390..4832974 + 585 WP_004182816.1 TetR/AcrR family transcriptional regulator -
QSV42_RS23990 (QSV42_23985) 4832996..4833799 + 804 WP_012969028.1 winged helix-turn-helix domain-containing protein -
QSV42_RS23995 (QSV42_23990) 4833796..4834314 + 519 WP_023322003.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11245.77 Da        Isoelectric Point: 8.6574

>T284621 WP_012542979.1 NZ_CP128466:c4829890-4829603 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11320.98 Da        Isoelectric Point: 10.3129

>AT284621 WP_022065028.1 NZ_CP128466:c4829616-4829314 [Klebsiella variicola]
MSMVKHKRGNTAALTAKRDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References