Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2676080..2677668 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QSV42_RS13435 Protein ID WP_229532791.1
Coordinates 2676080..2677402 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag QSV42_RS13440 Protein ID WP_008804920.1
Coordinates 2677402..2677668 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS13420 (QSV42_13420) 2671145..2673646 + 2502 WP_180264348.1 fimbria/pilus outer membrane usher protein -
QSV42_RS13425 (QSV42_13425) 2673634..2674638 + 1005 Protein_2546 fimbrial protein -
QSV42_RS13430 (QSV42_13430) 2674771..2676063 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
QSV42_RS13435 (QSV42_13435) 2676080..2677402 - 1323 WP_229532791.1 type II toxin-antitoxin system HipA family toxin Toxin
QSV42_RS13440 (QSV42_13440) 2677402..2677668 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QSV42_RS13445 (QSV42_13445) 2677934..2678260 - 327 WP_008804921.1 hydroxyisourate hydrolase -
QSV42_RS13450 (QSV42_13450) 2678257..2678757 - 501 WP_131035681.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QSV42_RS13455 (QSV42_13455) 2678735..2680114 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
QSV42_RS13460 (QSV42_13460) 2680459..2681613 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
QSV42_RS13465 (QSV42_13465) 2681594..2682517 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48868.24 Da        Isoelectric Point: 7.5644

>T284618 WP_229532791.1 NZ_CP128466:c2677402-2676080 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFLYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT284618 WP_008804920.1 NZ_CP128466:c2677668-2677402 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References