Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1797266..1797856 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name pemK Uniprot ID A0A1F2LYA2
Locus tag QSV42_RS09045 Protein ID WP_008804165.1
Coordinates 1797524..1797856 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1F2LZQ3
Locus tag QSV42_RS09040 Protein ID WP_012541132.1
Coordinates 1797266..1797523 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS09020 (QSV42_09020) 1792873..1793448 + 576 WP_012541129.1 hypothetical protein -
QSV42_RS09025 (QSV42_09025) 1793627..1794463 + 837 WP_289642568.1 alpha/beta hydrolase -
QSV42_RS09030 (QSV42_09030) 1794669..1795640 + 972 WP_012541130.1 sensor domain-containing diguanylate cyclase -
QSV42_RS09035 (QSV42_09035) 1795637..1796737 - 1101 WP_048268588.1 AarF/UbiB family protein -
QSV42_RS09040 (QSV42_09040) 1797266..1797523 + 258 WP_012541132.1 antitoxin Antitoxin
QSV42_RS09045 (QSV42_09045) 1797524..1797856 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QSV42_RS09055 (QSV42_09055) 1798179..1799615 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
QSV42_RS09065 (QSV42_09065) 1799988..1801442 - 1455 WP_008804170.1 AMP nucleosidase -
QSV42_RS09070 (QSV42_09070) 1801571..1801816 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11867.71 Da        Isoelectric Point: 10.1839

>T284613 WP_008804165.1 NZ_CP128466:1797524-1797856 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9420.91 Da        Isoelectric Point: 4.4915

>AT284613 WP_012541132.1 NZ_CP128466:1797266-1797523 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2LYA2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZQ3

References