Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1605624..1606621 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QSV42_RS08240 Protein ID WP_232690963.1
Coordinates 1606067..1606621 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QSV42_RS08235 Protein ID WP_042947869.1
Coordinates 1605624..1606070 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS08220 (QSV42_08220) 1601919..1602917 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
QSV42_RS08225 (QSV42_08225) 1603036..1604556 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
QSV42_RS08230 (QSV42_08230) 1604572..1605582 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
QSV42_RS08235 (QSV42_08235) 1605624..1606070 - 447 WP_042947869.1 helix-turn-helix transcriptional regulator Antitoxin
QSV42_RS08240 (QSV42_08240) 1606067..1606621 - 555 WP_232690963.1 HipA domain-containing protein Toxin
QSV42_RS08245 (QSV42_08245) 1606650..1607171 - 522 WP_064142799.1 hypothetical protein -
QSV42_RS08250 (QSV42_08250) 1607286..1608017 - 732 WP_008804033.1 outer membrane permeability protein SanA -
QSV42_RS08255 (QSV42_08255) 1608054..1608272 - 219 WP_289642545.1 hypothetical protein -
QSV42_RS08260 (QSV42_08260) 1608294..1609178 - 885 WP_064180626.1 cytidine deaminase -
QSV42_RS08265 (QSV42_08265) 1609307..1610002 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
QSV42_RS08270 (QSV42_08270) 1609992..1610396 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20724.01 Da        Isoelectric Point: 5.2868

>T284612 WP_232690963.1 NZ_CP128466:c1606621-1606067 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDYETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16410.08 Da        Isoelectric Point: 10.5417

>AT284612 WP_042947869.1 NZ_CP128466:c1606070-1605624 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRLEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References