Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 783814..784471 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QSV42_RS04300 Protein ID WP_002916310.1
Coordinates 784061..784471 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QSV42_RS04295 Protein ID WP_002916312.1
Coordinates 783814..784080 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS04270 (QSV42_04270) 778963..780396 - 1434 WP_012967244.1 6-phospho-beta-glucosidase BglA -
QSV42_RS04275 (QSV42_04275) 780516..781244 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
QSV42_RS04280 (QSV42_04280) 781295..781606 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
QSV42_RS04285 (QSV42_04285) 781770..782429 + 660 WP_008806429.1 hemolysin III family protein -
QSV42_RS04290 (QSV42_04290) 782585..783568 - 984 WP_072124459.1 tRNA-modifying protein YgfZ -
QSV42_RS04295 (QSV42_04295) 783814..784080 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QSV42_RS04300 (QSV42_04300) 784061..784471 + 411 WP_002916310.1 protein YgfX Toxin
QSV42_RS04305 (QSV42_04305) 784478..784999 - 522 WP_008806427.1 flavodoxin FldB -
QSV42_RS04310 (QSV42_04310) 785100..785996 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
QSV42_RS04315 (QSV42_04315) 786019..786732 + 714 WP_012540593.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QSV42_RS04320 (QSV42_04320) 786738..788471 + 1734 WP_117106322.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T284611 WP_002916310.1 NZ_CP128466:784061-784471 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT284611 WP_002916312.1 NZ_CP128466:783814-784080 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References