Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2763829..2764400 Replicon chromosome
Accession NZ_CP128464
Organism Enterococcus faecalis strain RE25

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag QSV41_RS14010 Protein ID WP_002360937.1
Coordinates 2763829..2764170 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag QSV41_RS14015 Protein ID WP_002367500.1
Coordinates 2764170..2764400 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV41_RS14005 (2759844) 2759844..2763458 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QSV41_RS14010 (2763829) 2763829..2764170 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QSV41_RS14015 (2764170) 2764170..2764400 - 231 WP_002367500.1 hypothetical protein Antitoxin
QSV41_RS14020 (2764455) 2764455..2764634 - 180 WP_111997057.1 hypothetical protein -
QSV41_RS14025 (2764814) 2764814..2765029 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QSV41_RS14030 (2765168) 2765168..2766160 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
QSV41_RS14035 (2766424) 2766424..2767062 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QSV41_RS14040 (2767748) 2767748..2769364 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T284598 WP_002360937.1 NZ_CP128464:c2764170-2763829 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT284598 WP_002367500.1 NZ_CP128464:c2764400-2764170 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References