Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 2382747..2383445 Replicon chromosome
Accession NZ_CP128464
Organism Enterococcus faecalis strain RE25

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QSV41_RS12245 Protein ID WP_202274464.1
Coordinates 2383101..2383445 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QSV41_RS12240 Protein ID WP_023895324.1
Coordinates 2382747..2383082 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV41_RS12200 (2378400) 2378400..2379176 - 777 WP_010816191.1 DnaD domain protein -
QSV41_RS12205 (2379192) 2379192..2380007 - 816 WP_010816192.1 PD-(D/E)XK nuclease-like domain-containing protein -
QSV41_RS12210 (2379970) 2379970..2380935 - 966 WP_010717378.1 RecT family recombinase -
QSV41_RS12215 (2381036) 2381036..2381260 - 225 WP_002367281.1 hypothetical protein -
QSV41_RS12220 (2381369) 2381369..2381785 - 417 WP_289690717.1 hypothetical protein -
QSV41_RS12225 (2381786) 2381786..2381956 - 171 WP_002405829.1 hypothetical protein -
QSV41_RS12230 (2381991) 2381991..2382260 - 270 WP_202274460.1 hypothetical protein -
QSV41_RS12235 (2382273) 2382273..2382455 - 183 WP_002358110.1 hypothetical protein -
QSV41_RS12240 (2382747) 2382747..2383082 + 336 WP_023895324.1 helix-turn-helix transcriptional regulator Antitoxin
QSV41_RS12245 (2383101) 2383101..2383445 + 345 WP_202274464.1 ImmA/IrrE family metallo-endopeptidase Toxin
QSV41_RS12250 (2383503) 2383503..2384231 + 729 WP_002380840.1 potassium channel family protein -
QSV41_RS12255 (2384386) 2384386..2385567 + 1182 WP_104844184.1 site-specific integrase -
QSV41_RS12260 (2385670) 2385670..2385819 - 150 WP_002356321.1 50S ribosomal protein L33 -
QSV41_RS12265 (2385945) 2385945..2388080 - 2136 WP_002362471.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2348730..2385567 36837


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-60)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13666.67 Da        Isoelectric Point: 5.2241

>T284587 WP_202274464.1 NZ_CP128464:2383101-2383445 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMELYKIPAFRSKMESEAEQ
YMFRILIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12843.45 Da        Isoelectric Point: 4.8252

>AT284587 WP_023895324.1 NZ_CP128464:2382747-2383082 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References