284584

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 411587..412169 Replicon chromosome
Accession NZ_CP128464
Organism Enterococcus faecalis strain RE25

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag QSV41_RS02430 Protein ID WP_002355414.1
Coordinates 411861..412169 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QSV41_RS02425 Protein ID WP_002326825.1
Coordinates 411587..411859 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV41_RS02395 (406868) 406868..407596 - 729 WP_002355404.1 GntR family transcriptional regulator -
QSV41_RS02400 (407773) 407773..408699 + 927 WP_002355406.1 hypothetical protein -
QSV41_RS02405 (408716) 408716..409999 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
QSV41_RS02410 (410191) 410191..410313 + 123 Protein_381 topoisomerase -
QSV41_RS02415 (410388) 410388..411284 + 897 WP_002363034.1 ParA family protein -
QSV41_RS02420 (411361) 411361..411570 + 210 WP_002363035.1 peptide-binding protein -
QSV41_RS02425 (411587) 411587..411859 + 273 WP_002326825.1 antitoxin Antitoxin
QSV41_RS02430 (411861) 411861..412169 + 309 WP_002355414.1 zeta toxin family protein Toxin
QSV41_RS02435 (412249) 412249..412656 - 408 WP_224571294.1 tyrosine-type recombinase/integrase -
QSV41_RS02440 (412723) 412723..413223 - 501 WP_002363039.1 HAD family hydrolase -
QSV41_RS02445 (413228) 413228..413995 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
QSV41_RS02450 (414482) 414482..414907 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
QSV41_RS02455 (414924) 414924..415439 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
QSV41_RS02460 (415450) 415450..416382 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T284584 WP_002355414.1 NZ_CP128464:411861-412169 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT284584 WP_002326825.1 NZ_CP128464:411587-411859 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References