284582

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 36011..36542 Replicon plasmid pRE25
Accession NZ_CP128463
Organism Enterococcus faecalis strain RE25

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag QSV41_RS00270 Protein ID WP_176454448.1
Coordinates 36011..36268 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL01
Locus tag QSV41_RS00275 Protein ID WP_002331065.1
Coordinates 36270..36542 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV41_RS00245 (QSV41_00245) 31604..32766 + 1163 WP_086953888.1 IS3 family transposase -
QSV41_RS00250 (QSV41_00250) 32942..33439 + 498 WP_228780308.1 IS3 family transposase -
QSV41_RS00255 (QSV41_00255) 33912..34484 - 573 WP_000170424.1 recombinase family protein -
QSV41_RS00260 (QSV41_00260) 34500..35105 - 606 WP_000599739.1 Fic family protein -
QSV41_RS00265 (QSV41_00265) 35303..35983 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
QSV41_RS00270 (QSV41_00270) 36011..36268 - 258 WP_176454448.1 zeta toxin family protein Toxin
QSV41_RS00275 (QSV41_00275) 36270..36542 - 273 WP_002331065.1 antitoxin Antitoxin
QSV41_RS00280 (QSV41_00280) 36559..36768 - 210 WP_000527318.1 peptide-binding protein -
QSV41_RS00285 (QSV41_00285) 36867..37763 - 897 WP_002334978.1 AAA family ATPase -
QSV41_RS00290 (QSV41_00290) 38061..38633 - 573 WP_001079938.1 HTH domain-containing protein -
QSV41_RS00295 (QSV41_00295) 38909..39703 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
QSV41_RS00300 (QSV41_00300) 39796..40338 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
QSV41_RS00305 (QSV41_00305) 40335..41243 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) / cat(pC221) / aph(3')-III / ant(6)-Ia - 1..50228 50228
- inside IScluster/Tn erm(B) / cat(pC221) / aph(3')-III / ant(6)-Ia - 15246..44068 28822


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-73)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9565.90 Da        Isoelectric Point: 6.2869

>T284582 WP_176454448.1 NZ_CP128463:c36268-36011 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKRFCCKVLNLL
SNKVE

Download         Length: 258 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10733.17 Da        Isoelectric Point: 4.4865

>AT284582 WP_002331065.1 NZ_CP128463:c36542-36270 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZL55

References