Detailed information of TA system
Overview
TA module
| Type | VII | Classification (family/domain) | HepT-MntA/HepT(toxin) |
| Location | 2549061..2549877 | Replicon | chromosome |
| Accession | NZ_CP128459 | ||
| Organism | Geobacillus stearothermophilus strain EF60134 | ||
Toxin (Protein)
| Gene name | hepT | Uniprot ID | G8MYR9 |
| Locus tag | QT238_RS13365 | Protein ID | WP_014195290.1 |
| Coordinates | 2549458..2549877 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | mntA | Uniprot ID | - |
| Locus tag | QT238_RS13360 | Protein ID | WP_289667385.1 |
| Coordinates | 2549061..2549468 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QT238_RS13345 (QT238_13345) | 2544427..2545464 | - | 1038 | WP_253264117.1 | hypothetical protein | - |
| QT238_RS13350 (QT238_13350) | 2545634..2546380 | - | 747 | Protein_2568 | FixH family protein | - |
| QT238_RS13355 (QT238_13355) | 2546648..2548780 | + | 2133 | WP_289667965.1 | AAA family ATPase | - |
| QT238_RS13360 (QT238_13360) | 2549061..2549468 | + | 408 | WP_289667385.1 | nucleotidyltransferase domain-containing protein | Antitoxin |
| QT238_RS13365 (QT238_13365) | 2549458..2549877 | + | 420 | WP_014195290.1 | DUF86 domain-containing protein | Toxin |
| QT238_RS13370 (QT238_13370) | 2549905..2550000 | - | 96 | Protein_2572 | TetR/AcrR family transcriptional regulator | - |
| QT238_RS13375 (QT238_13375) | 2550020..2550538 | - | 519 | WP_277391694.1 | GNAT family N-acetyltransferase | - |
| QT238_RS13380 (QT238_13380) | 2550618..2552312 | - | 1695 | WP_289667966.1 | M3 family oligoendopeptidase | - |
| QT238_RS13385 (QT238_13385) | 2552884..2553156 | + | 273 | Protein_2575 | amino acid permease | - |
| QT238_RS13390 (QT238_13390) | 2553402..2553812 | + | 411 | Protein_2576 | zinc ribbon domain-containing protein | - |
| QT238_RS13395 (QT238_13395) | 2553882..2554301 | + | 420 | Protein_2577 | prolyl oligopeptidase family serine peptidase | - |
| QT238_RS13400 (QT238_13400) | 2554320..2554853 | + | 534 | WP_289667967.1 | short-chain dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15907.43 Da Isoelectric Point: 8.2859
>T284580 WP_014195290.1 NZ_CP128459:2549458-2549877 [Geobacillus stearothermophilus]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS
Download Length: 420 bp
>T284580 NZ_CP128459:2549458-2549877 [Geobacillus stearothermophilus]
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATTGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACAGCTAG
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATTGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACAGCTAG
Antitoxin
Download Length: 136 a.a. Molecular weight: 15230.44 Da Isoelectric Point: 4.6940
>AT284580 WP_289667385.1 NZ_CP128459:2549061-2549468 [Geobacillus stearothermophilus]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGLDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGLDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK
Download Length: 408 bp
>AT284580 NZ_CP128459:2549061-2549468 [Geobacillus stearothermophilus]
TTGCCAAACGAAATGGAGACGATCATCATTCAGACGCTCCGCCCGGCTCTTCACCCGTTCGTCATCTACCTGTTCGGTTC
AGCCGCCCGTGGGACGCTGCGCCCAGACAGCGATGTCGATATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATG
AGCTGTTTCGGCTCGCCGGGGAGTTGGCTGACAAGTTAGGGCTCGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACC
GTGTTTCAAGCGCAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAA
AACATTGAAAATGTATGTGAAACTAAACGAAGAGAGAGCACCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATG
AAAAGTGA
TTGCCAAACGAAATGGAGACGATCATCATTCAGACGCTCCGCCCGGCTCTTCACCCGTTCGTCATCTACCTGTTCGGTTC
AGCCGCCCGTGGGACGCTGCGCCCAGACAGCGATGTCGATATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATG
AGCTGTTTCGGCTCGCCGGGGAGTTGGCTGACAAGTTAGGGCTCGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACC
GTGTTTCAAGCGCAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAA
AACATTGAAAATGTATGTGAAACTAAACGAAGAGAGAGCACCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATG
AAAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|