Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 980457..981273 Replicon chromosome
Accession NZ_CP128458
Organism Geobacillus stearothermophilus strain EF60133

Toxin (Protein)


Gene name hepT Uniprot ID G8MYR9
Locus tag QT237_RS05110 Protein ID WP_014195290.1
Coordinates 980457..980876 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag QT237_RS05115 Protein ID WP_289667385.1
Coordinates 980866..981273 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT237_RS05090 (QT237_05090) 976098..977309 - 1212 WP_289667382.1 amino acid permease -
QT237_RS05095 (QT237_05095) 977881..979575 + 1695 WP_289667383.1 M3 family oligoendopeptidase -
QT237_RS05100 (QT237_05100) 979796..980314 + 519 WP_289667384.1 GNAT family N-acetyltransferase -
QT237_RS05105 (QT237_05105) 980334..980429 + 96 Protein_943 TetR/AcrR family transcriptional regulator -
QT237_RS05110 (QT237_05110) 980457..980876 - 420 WP_014195290.1 DUF86 domain-containing protein Toxin
QT237_RS05115 (QT237_05115) 980866..981273 - 408 WP_289667385.1 nucleotidyltransferase domain-containing protein Antitoxin
QT237_RS05120 (QT237_05120) 981554..983686 - 2133 WP_289667386.1 AAA family ATPase -
QT237_RS05125 (QT237_05125) 983954..984700 + 747 WP_081132891.1 FixH family protein -
QT237_RS05130 (QT237_05130) 984809..985849 + 1041 WP_023634222.1 membrane protein -
QT237_RS05135 (QT237_05135) 985934..986095 - 162 WP_160149182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15907.43 Da        Isoelectric Point: 8.2859

>T284578 WP_014195290.1 NZ_CP128458:c980876-980457 [Geobacillus stearothermophilus]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS

Download         Length: 420 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15230.44 Da        Isoelectric Point: 4.6940

>AT284578 WP_289667385.1 NZ_CP128458:c981273-980866 [Geobacillus stearothermophilus]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGLDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8MYR9

Antitoxin

Source ID Structure

References