Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) doc-NpoA/Fic(toxin)
Location 745392..746672 Replicon chromosome
Accession NZ_CP128458
Organism Geobacillus stearothermophilus strain EF60133

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag QT237_RS03880 Protein ID WP_289667301.1
Coordinates 746358..746672 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name NpoA Uniprot ID -
Locus tag QT237_RS03875 Protein ID WP_289667300.1
Coordinates 745392..746255 (-) Length 288 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT237_RS03860 (QT237_03860) 741124..742524 - 1401 WP_289643708.1 ISLre2-like element ISGsp4 family transposase -
QT237_RS03865 (QT237_03865) 742842..743720 + 879 WP_014195145.1 IS982 family transposase -
QT237_RS03870 (QT237_03870) 744059..745258 + 1200 WP_033010559.1 L-2-hydroxyglutarate oxidase -
QT237_RS03875 (QT237_03875) 745392..746255 - 864 WP_289667300.1 SDR family oxidoreductase Antitoxin
QT237_RS03880 (QT237_03880) 746358..746672 - 315 WP_289667301.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QT237_RS03885 (QT237_03885) 746789..747082 + 294 WP_013146163.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QT237_RS03890 (QT237_03890) 747107..747526 + 420 WP_289667302.1 type II toxin-antitoxin system VapC family toxin -
QT237_RS03895 (QT237_03895) 747687..751097 - 3411 WP_289667303.1 methionine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(28-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12027.78 Da        Isoelectric Point: 9.4472

>T284577 WP_289667301.1 NZ_CP128458:c746672-746358 [Geobacillus stearothermophilus]
MFPKFPELLNSAVNRPKQSAFGQDAYPTLWLKAAALYASLCQNHPFHNANKRTGFAAMKQFLWLNGYRFAASEKEAEDYT
VKVVTDKPSIEEIAMWIERWAEKR

Download         Length: 315 bp

Antitoxin


Download         Length: 288 a.a.        Molecular weight: 30712.91 Da        Isoelectric Point: 7.3723

>AT284577 WP_289667300.1 NZ_CP128458:c746255-745392 [Geobacillus stearothermophilus]
MVTKQQTTLPPQHQTRQPGLQTEMNPQPVTIKDSYKGSGKLKNKTAIISGGDSGIGRAVAVHFAKEGADVAILYLNEHED
ADETKRLVEQEGRRCLAIAGDIGDEAFCKEAVKQTIEAFGKLDIVVNNAAEQHPQPNFLNITAAQLEKTFRTNVFGCFFL
TKAALPHLKSGSAIINTASITAYEGNEQLIDYSATKGAIVAFTRSLAKALVGQGIRVNGVAPGPIWTPLIPSTFTSDQVA
TFGSNTPMKRPGQPCEVAPSYVFLASEEASYITGQMIHVNGGKIVNG

Download         Length: 864 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References