Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | doc-NpoA/Fic(toxin) |
| Location | 646632..647991 | Replicon | chromosome |
| Accession | NZ_CP128454 | ||
| Organism | Geobacillus stearothermophilus strain EF60063 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A150MRT2 |
| Locus tag | QT236_RS03350 | Protein ID | WP_033013801.1 |
| Coordinates | 647599..647991 (-) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | NpoA | Uniprot ID | - |
| Locus tag | QT236_RS03345 | Protein ID | WP_289651915.1 |
| Coordinates | 646632..647495 (-) | Length | 288 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QT236_RS03315 (QT236_03315) | 642052..643071 | + | 1020 | WP_289651907.1 | LacI family DNA-binding transcriptional regulator | - |
| QT236_RS03320 (QT236_03320) | 643125..644012 | + | 888 | WP_289651908.1 | efflux RND transporter periplasmic adaptor subunit | - |
| QT236_RS03325 (QT236_03325) | 643952..644407 | + | 456 | WP_289651909.1 | ATP-binding protein | - |
| QT236_RS03330 (QT236_03330) | 644472..645167 | + | 696 | WP_289651911.1 | O-methyltransferase | - |
| QT236_RS03335 (QT236_03335) | 645241..645540 | + | 300 | WP_020279345.1 | hypothetical protein | - |
| QT236_RS03340 (QT236_03340) | 645576..645914 | + | 339 | WP_013146175.1 | antibiotic biosynthesis monooxygenase | - |
| QT236_RS03345 (QT236_03345) | 646632..647495 | - | 864 | WP_289651915.1 | SDR family oxidoreductase | Antitoxin |
| QT236_RS03350 (QT236_03350) | 647599..647991 | - | 393 | WP_033013801.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| QT236_RS03355 (QT236_03355) | 648004..648276 | - | 273 | WP_033013800.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| QT236_RS03360 (QT236_03360) | 648425..651835 | - | 3411 | WP_289651918.1 | methionine synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14980.35 Da Isoelectric Point: 8.8161
>T284575 WP_033013801.1 NZ_CP128454:c647991-647599 [Geobacillus stearothermophilus]
MTRFLTEKEIIFLNALLIEKYTPEEQKGVKFPELLNSAVNRPKQSAFGQDAYPTLWLKAAALYASLCQNHPFHNANKRTG
FAAMKQFLWLNGYLLAAPEKEAEEYTVKVVTDKPSIEEIAMWIETWAKKR
MTRFLTEKEIIFLNALLIEKYTPEEQKGVKFPELLNSAVNRPKQSAFGQDAYPTLWLKAAALYASLCQNHPFHNANKRTG
FAAMKQFLWLNGYLLAAPEKEAEEYTVKVVTDKPSIEEIAMWIETWAKKR
Download Length: 393 bp
Antitoxin
Download Length: 288 a.a. Molecular weight: 30901.17 Da Isoelectric Point: 7.3717
>AT284575 WP_289651915.1 NZ_CP128454:c647495-646632 [Geobacillus stearothermophilus]
MVTKQQTTLPPQHQTRQPGLQTEMNPQPVTIKDTYKGSGKLKNKTAIISGGDSGIGRAVAVHFAKEGADVAIIYLNEHED
AEETKRLVEQEGRRCLAMAGDIGDEAFCKEAVKQTIEAFGKLDIVVNNAAEQHPQPNFLNITAAQLEKTFRTNVFGYFFL
TKAALPHLKNGSAIINTASVTAYEGNEQLIDYSATKGAIVAFTRSLAKALVGQGIRVNGVAPGPIWTPLIPSTFKSEQVA
TFGANTPMKRPGQPCEVAPCYVFLASDESSYMTGQMLHVDGGKFVSG
MVTKQQTTLPPQHQTRQPGLQTEMNPQPVTIKDTYKGSGKLKNKTAIISGGDSGIGRAVAVHFAKEGADVAIIYLNEHED
AEETKRLVEQEGRRCLAMAGDIGDEAFCKEAVKQTIEAFGKLDIVVNNAAEQHPQPNFLNITAAQLEKTFRTNVFGYFFL
TKAALPHLKNGSAIINTASVTAYEGNEQLIDYSATKGAIVAFTRSLAKALVGQGIRVNGVAPGPIWTPLIPSTFKSEQVA
TFGANTPMKRPGQPCEVAPCYVFLASDESSYMTGQMLHVDGGKFVSG
Download Length: 864 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|