284573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 1022751..1023567 Replicon chromosome
Accession NZ_CP128453
Organism Geobacillus stearothermophilus strain EF60045

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag QT235_RS05355 Protein ID WP_289643806.1
Coordinates 1022751..1023170 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag QT235_RS05360 Protein ID WP_289643807.1
Coordinates 1023160..1023567 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT235_RS05325 (QT235_05325) 1018470..1018709 - 240 Protein_987 transposase -
QT235_RS05330 (QT235_05330) 1019020..1020714 + 1695 WP_289643802.1 M3 family oligoendopeptidase -
QT235_RS05335 (QT235_05335) 1020805..1021320 + 516 WP_289643803.1 GNAT family N-acetyltransferase -
QT235_RS05340 (QT235_05340) 1021409..1021621 + 213 WP_069304090.1 ATP-binding cassette domain-containing protein -
QT235_RS05345 (QT235_05345) 1021588..1022058 + 471 Protein_991 ABC transporter permease -
QT235_RS05350 (QT235_05350) 1022070..1022723 + 654 WP_289643805.1 helix-turn-helix domain-containing protein -
QT235_RS05355 (QT235_05355) 1022751..1023170 - 420 WP_289643806.1 DUF86 domain-containing protein Toxin
QT235_RS05360 (QT235_05360) 1023160..1023567 - 408 WP_289643807.1 nucleotidyltransferase domain-containing protein Antitoxin
QT235_RS05365 (QT235_05365) 1023848..1025980 - 2133 WP_289643808.1 AAA family ATPase -
QT235_RS05370 (QT235_05370) 1026248..1026994 + 747 WP_033011882.1 FixH family protein -
QT235_RS05375 (QT235_05375) 1027164..1028204 + 1041 WP_289643809.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16017.42 Da        Isoelectric Point: 6.9655

>T284573 WP_289643806.1 NZ_CP128453:c1023170-1022751 [Geobacillus stearothermophilus]
MKHDVILNKISIIERCLRRINEEYEHDPKNLQNYTKQDSIILNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFSLLEEH
GVISPAVSQNMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKHFAKAILDYAKKNS

Download         Length: 420 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15243.41 Da        Isoelectric Point: 4.8349

>AT284573 WP_289643807.1 NZ_CP128453:c1023567-1023160 [Geobacillus stearothermophilus]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQAST
VFQAQVVSSGKVIDCGDERKRMEFEMKTLKMYAKLNEEREPVLKRIAESGSVYET

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References