Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 902129..902945 Replicon chromosome
Accession NZ_CP128449
Organism Geobacillus stearothermophilus strain SJEF4-2

Toxin (Protein)


Gene name hepT Uniprot ID G8MYR9
Locus tag QT234_RS04680 Protein ID WP_014195290.1
Coordinates 902129..902548 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID G8MYS0
Locus tag QT234_RS04685 Protein ID WP_014195291.1
Coordinates 902538..902945 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT234_RS04660 (QT234_04665) 898993..900687 + 1695 WP_289652011.1 M3 family oligoendopeptidase -
QT234_RS04665 (QT234_04670) 900908..901426 + 519 WP_289652012.1 GNAT family N-acetyltransferase -
QT234_RS04670 (QT234_04675) 901525..901662 + 138 Protein_856 ABC transporter permease -
QT234_RS04675 (QT234_04680) 901664..902101 + 438 Protein_857 TetR/AcrR family transcriptional regulator -
QT234_RS04680 (QT234_04685) 902129..902548 - 420 WP_014195290.1 DUF86 domain-containing protein Toxin
QT234_RS04685 (QT234_04690) 902538..902945 - 408 WP_014195291.1 nucleotidyltransferase domain-containing protein Antitoxin
QT234_RS04690 (QT234_04695) 903132..903731 - 600 WP_011230467.1 hypothetical protein -
QT234_RS04695 (QT234_04700) 903753..904265 - 513 WP_020754942.1 hypothetical protein -
QT234_RS04700 (QT234_04705) 904487..906622 - 2136 WP_289652013.1 ATP-dependent Clp protease ATP-binding subunit -
QT234_RS04705 (QT234_04710) 906890..907636 + 747 WP_081132891.1 FixH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15907.43 Da        Isoelectric Point: 8.2859

>T284571 WP_014195290.1 NZ_CP128449:c902548-902129 [Geobacillus stearothermophilus]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS

Download         Length: 420 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15273.46 Da        Isoelectric Point: 4.8382

>AT284571 WP_014195291.1 NZ_CP128449:c902945-902538 [Geobacillus stearothermophilus]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGRDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8MYR9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9EPL2

References