Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | HepT-MntA/HepT(toxin) |
Location | 902129..902945 | Replicon | chromosome |
Accession | NZ_CP128449 | ||
Organism | Geobacillus stearothermophilus strain SJEF4-2 |
Toxin (Protein)
Gene name | hepT | Uniprot ID | G8MYR9 |
Locus tag | QT234_RS04680 | Protein ID | WP_014195290.1 |
Coordinates | 902129..902548 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | mntA | Uniprot ID | G8MYS0 |
Locus tag | QT234_RS04685 | Protein ID | WP_014195291.1 |
Coordinates | 902538..902945 (-) | Length | 136 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QT234_RS04660 (QT234_04665) | 898993..900687 | + | 1695 | WP_289652011.1 | M3 family oligoendopeptidase | - |
QT234_RS04665 (QT234_04670) | 900908..901426 | + | 519 | WP_289652012.1 | GNAT family N-acetyltransferase | - |
QT234_RS04670 (QT234_04675) | 901525..901662 | + | 138 | Protein_856 | ABC transporter permease | - |
QT234_RS04675 (QT234_04680) | 901664..902101 | + | 438 | Protein_857 | TetR/AcrR family transcriptional regulator | - |
QT234_RS04680 (QT234_04685) | 902129..902548 | - | 420 | WP_014195290.1 | DUF86 domain-containing protein | Toxin |
QT234_RS04685 (QT234_04690) | 902538..902945 | - | 408 | WP_014195291.1 | nucleotidyltransferase domain-containing protein | Antitoxin |
QT234_RS04690 (QT234_04695) | 903132..903731 | - | 600 | WP_011230467.1 | hypothetical protein | - |
QT234_RS04695 (QT234_04700) | 903753..904265 | - | 513 | WP_020754942.1 | hypothetical protein | - |
QT234_RS04700 (QT234_04705) | 904487..906622 | - | 2136 | WP_289652013.1 | ATP-dependent Clp protease ATP-binding subunit | - |
QT234_RS04705 (QT234_04710) | 906890..907636 | + | 747 | WP_081132891.1 | FixH family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15907.43 Da Isoelectric Point: 8.2859
>T284571 WP_014195290.1 NZ_CP128449:c902548-902129 [Geobacillus stearothermophilus]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS
Download Length: 420 bp
Antitoxin
Download Length: 136 a.a. Molecular weight: 15273.46 Da Isoelectric Point: 4.8382
>AT284571 WP_014195291.1 NZ_CP128449:c902945-902538 [Geobacillus stearothermophilus]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGRDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGRDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK
Download Length: 408 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G8MYR9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9EPL2 |