284569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 233853..234489 Replicon chromosome
Accession NZ_CP128449
Organism Geobacillus stearothermophilus strain SJEF4-2

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag QT234_RS01270 Protein ID WP_003253417.1
Coordinates 234139..234489 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A087LE06
Locus tag QT234_RS01265 Protein ID WP_033010302.1
Coordinates 233853..234134 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QT234_RS01245 (QT234_01245) 230105..230722 - 618 WP_033010298.1 rhomboid family intramembrane serine protease -
QT234_RS01250 (QT234_01250) 230841..231230 + 390 WP_033010299.1 holo-ACP synthase -
QT234_RS01255 (QT234_01255) 231310..232329 + 1020 WP_277391990.1 outer membrane lipoprotein carrier protein LolA -
QT234_RS01260 (QT234_01260) 232572..233738 + 1167 WP_033010307.1 alanine racemase -
QT234_RS01265 (QT234_01265) 233853..234134 + 282 WP_033010302.1 hypothetical protein Antitoxin
QT234_RS01270 (QT234_01270) 234139..234489 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QT234_RS01275 (QT234_01275) 235032..237194 + 2163 WP_061580987.1 Tex family protein -
QT234_RS01280 (QT234_01280) 237252..237365 - 114 WP_094239478.1 cortex morphogenetic protein CmpA -
QT234_RS01285 (QT234_01285) 237459..237920 + 462 WP_033016555.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T284569 WP_003253417.1 NZ_CP128449:234139-234489 [Geobacillus stearothermophilus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10683.20 Da        Isoelectric Point: 7.2027

>AT284569 WP_033010302.1 NZ_CP128449:233853-234134 [Geobacillus stearothermophilus]
VSESGATTEIIVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A087LE06

References