Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 561821..562474 Replicon chromosome
Accession NZ_CP128411
Organism Brevibacillus brevis strain HNCS-1

Toxin (Protein)


Gene name mazF Uniprot ID J2PLP3
Locus tag QN310_RS03040 Protein ID WP_005830205.1
Coordinates 562124..562474 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J2GZH3
Locus tag QN310_RS03035 Protein ID WP_007721089.1
Coordinates 561821..562120 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN310_RS03020 (QN310_03020) 558386..559759 + 1374 WP_289675964.1 hypothetical protein -
QN310_RS03025 (QN310_03025) 559945..560385 + 441 WP_012684242.1 hypothetical protein -
QN310_RS03030 (QN310_03030) 560388..561590 + 1203 WP_289675965.1 alanine racemase -
QN310_RS03035 (QN310_03035) 561821..562120 + 300 WP_007721089.1 CopG family ribbon-helix-helix protein Antitoxin
QN310_RS03040 (QN310_03040) 562124..562474 + 351 WP_005830205.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QN310_RS03045 (QN310_03045) 562767..563111 + 345 WP_235442569.1 anti-sigma regulatory factor -
QN310_RS03050 (QN310_03050) 563117..564118 + 1002 WP_289675966.1 PP2C family protein-serine/threonine phosphatase -
QN310_RS03055 (QN310_03055) 564142..564468 + 327 WP_012684246.1 anti-sigma factor antagonist -
QN310_RS03060 (QN310_03060) 564468..564962 + 495 WP_087345518.1 anti-sigma B factor RsbW -
QN310_RS03065 (QN310_03065) 564931..565719 + 789 WP_172142754.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-52)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12917.86 Da        Isoelectric Point: 4.8435

>T284549 WP_005830205.1 NZ_CP128411:562124-562474 [Brevibacillus brevis]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVNESLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11309.19 Da        Isoelectric Point: 10.2101

>AT284549 WP_007721089.1 NZ_CP128411:561821-562120 [Brevibacillus brevis]
MVGGGFVLSKSNTKRIMISLPQHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRTIRETMQKGYMEMAKINLNMASE
AFGAEEEADHTLVRLVSGV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2PLP3

Antitoxin

Source ID Structure
AlphaFold DB J2GZH3

References