Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2254471..2255000 Replicon chromosome
Accession NZ_CP128389
Organism Staphylococcus aureus strain 21-024

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QTN91_RS10835 Protein ID WP_000621175.1
Coordinates 2254638..2255000 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QTN91_RS10830 Protein ID WP_000948331.1
Coordinates 2254471..2254641 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN91_RS10800 (QTN91_10800) 2249507..2250067 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
QTN91_RS10805 (QTN91_10805) 2250276..2250755 + 480 WP_001287081.1 hypothetical protein -
QTN91_RS10810 (QTN91_10810) 2250748..2252325 + 1578 WP_001294650.1 PH domain-containing protein -
QTN91_RS10815 (QTN91_10815) 2252318..2252809 + 492 WP_001286980.1 PH domain-containing protein -
QTN91_RS10820 (QTN91_10820) 2252813..2253172 + 360 WP_000581197.1 holo-ACP synthase -
QTN91_RS10825 (QTN91_10825) 2253238..2254386 + 1149 WP_001281139.1 alanine racemase -
QTN91_RS10830 (QTN91_10830) 2254471..2254641 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QTN91_RS10835 (QTN91_10835) 2254638..2255000 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QTN91_RS10840 (QTN91_10840) 2255350..2256351 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QTN91_RS10845 (QTN91_10845) 2256470..2256796 + 327 WP_001052491.1 anti-sigma factor antagonist -
QTN91_RS10850 (QTN91_10850) 2256798..2257277 + 480 WP_001190825.1 anti-sigma B factor RsbW -
QTN91_RS10855 (QTN91_10855) 2257252..2258022 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T284542 WP_000621175.1 NZ_CP128389:2254638-2255000 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT284542 WP_000948331.1 NZ_CP128389:2254471-2254641 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References