Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2234749..2235263 Replicon chromosome
Accession NZ_CP128389
Organism Staphylococcus aureus strain 21-024

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QTN91_RS10745 Protein ID WP_000581792.1
Coordinates 2235054..2235263 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QTN91_RS10740 Protein ID WP_000138932.1
Coordinates 2234749..2235042 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN91_RS10720 (QTN91_10720) 2230512..2231827 + 1316 Protein_2106 ISL3 family transposase -
QTN91_RS10725 (QTN91_10725) 2231805..2231867 - 63 Protein_2107 hypothetical protein -
QTN91_RS10730 (QTN91_10730) 2232424..2233071 - 648 WP_001187614.1 HD domain-containing protein -
QTN91_RS10735 (QTN91_10735) 2233099..2234583 - 1485 WP_000571550.1 cardiolipin synthase -
QTN91_RS10740 (QTN91_10740) 2234749..2235042 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QTN91_RS10745 (QTN91_10745) 2235054..2235263 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QTN91_RS10750 (QTN91_10750) 2235391..2235528 + 138 WP_000828354.1 Lmo0850 family protein -
QTN91_RS10755 (QTN91_10755) 2235792..2236994 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QTN91_RS10760 (QTN91_10760) 2237312..2238382 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
QTN91_RS10765 (QTN91_10765) 2238397..2239752 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T284541 WP_000581792.1 NZ_CP128389:2235054-2235263 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT284541 WP_000138932.1 NZ_CP128389:2234749-2235042 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References