Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2420823..2421599 Replicon chromosome
Accession NZ_CP128388
Organism Staphylococcus aureus strain 21-074

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QTN92_RS11725 Protein ID WP_000031108.1
Coordinates 2421447..2421599 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QTN92_RS11720 Protein ID WP_001251224.1
Coordinates 2420823..2421422 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN92_RS11700 (QTN92_11700) 2416739..2418196 + 1458 WP_000649908.1 ABC transporter permease subunit -
QTN92_RS11705 (QTN92_11705) 2418189..2418911 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
QTN92_RS11710 (QTN92_11710) 2419062..2420189 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
QTN92_RS11715 (QTN92_11715) 2420194..2420664 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QTN92_RS11720 (QTN92_11720) 2420823..2421422 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QTN92_RS11725 (QTN92_11725) 2421447..2421599 + 153 WP_000031108.1 SAS053 family protein Toxin
QTN92_RS11730 (QTN92_11730) 2422142..2422537 + 396 WP_000901018.1 hypothetical protein -
QTN92_RS11735 (QTN92_11735) 2422733..2424118 + 1386 WP_000116238.1 class II fumarate hydratase -
QTN92_RS11740 (QTN92_11740) 2424573..2425394 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T284532 WP_000031108.1 NZ_CP128388:2421447-2421599 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT284532 WP_001251224.1 NZ_CP128388:2420823-2421422 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References