Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2259832..2260361 Replicon chromosome
Accession NZ_CP128388
Organism Staphylococcus aureus strain 21-074

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QTN92_RS10810 Protein ID WP_000621175.1
Coordinates 2259999..2260361 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag QTN92_RS10805 Protein ID WP_000948331.1
Coordinates 2259832..2260002 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN92_RS10775 (QTN92_10775) 2254868..2255428 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
QTN92_RS10780 (QTN92_10780) 2255637..2256116 + 480 WP_001287081.1 hypothetical protein -
QTN92_RS10785 (QTN92_10785) 2256109..2257686 + 1578 WP_001294650.1 PH domain-containing protein -
QTN92_RS10790 (QTN92_10790) 2257679..2258170 + 492 WP_001286980.1 PH domain-containing protein -
QTN92_RS10795 (QTN92_10795) 2258174..2258533 + 360 WP_000581197.1 holo-ACP synthase -
QTN92_RS10800 (QTN92_10800) 2258599..2259747 + 1149 WP_001281139.1 alanine racemase -
QTN92_RS10805 (QTN92_10805) 2259832..2260002 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QTN92_RS10810 (QTN92_10810) 2259999..2260361 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QTN92_RS10815 (QTN92_10815) 2260711..2261712 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QTN92_RS10820 (QTN92_10820) 2261831..2262157 + 327 WP_001052491.1 anti-sigma factor antagonist -
QTN92_RS10825 (QTN92_10825) 2262159..2262638 + 480 WP_001190825.1 anti-sigma B factor RsbW -
QTN92_RS10830 (QTN92_10830) 2262613..2263383 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T284531 WP_000621175.1 NZ_CP128388:2259999-2260361 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT284531 WP_000948331.1 NZ_CP128388:2259832-2260002 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References